… In this review, we focus on the clinical development of one target for cancer prevention, the
COX-2 enzyme. This provides an excellent example of how basic research in biochemistry …

… of COX-2 inhibition for the prevention of colon cancer. In addition to the use of COX-2 inhibitors
as … , as with cancer therapy, may require a combination of prevention agents. Employing …

… NSAIDs have any therapeutic effect in established colon cancer, whereas they may induce
… the expression of COX-2 in adenomas than in colon cancer. COX-2 mRNA, protein level, or …

… COX2 expression of the cells. In vivo, celecoxib as well as SC560 reduced the proliferation
of HCT15 (COX-2 deficient) colon cancer … tumors, which express COX-2 constitutively. Thus, …

… inhibition of cyclooxygenase 2 (COX-2). Cell 1996;87:803–9, … inhibition of cyclooxygenase
2 (COX-2). Cell 1996;87:803–9. … in mice lacking cyclooxygenase II. Nature 1995;378: 406–9. …

… effect of constitutive COX-2 expression in human colon cancer cells on the invasive potential
of these cells. Caco-2 cells normally express barely detectable levels of the COX-2 protein, …

… COX-2 mRNA and protein levels are increased in colon cancer tissues from patients and in
some colon cancer … The relationship between COX-2 and colon cancer is further confirmed …

… NOS) is overexpressed in colon cancers of humans and … COX-2 selective inhibitor, nimesulide,
in colon carcinogenesis in rats and mice, the involvement of prostanoid receptors in colon …

… COX-2–over-expressing Caco-2 colon cancer cells.17 Increased invasiveness and PGE 2
… , drawing a direct link between COX-2 and activation of MMPs. Murata et al.18 indicated that …

… with selective cyclooxygenase—2 (CQX—2) inhibitors including celecoxib and rofecoxib in
a variety of preclinical models of colon cancer. Naturally occurring COX-2 inhibitors such as …