… from patients with hereditary nonpolyposis colon cancer and in a subset of patients with
sporadic colorectal cancer (CRC). In sporadic CRC, three tumor phenotypes have been defined: …

… DNA in the serum of some patients with microsatellite unstable colon cancers. In a panel
of sera from 19 colon cancer cases, 9 with hMLH1 promoter methylation in the tumor primary, …

… instability in sporadic colorectal cancer often results … hMLH1 promoter methylation in 29
cancer cell lines derived from organs other than the colon (data not shown), including the hMLH1 …

… : Methylation of the hMLH1 promoter region has … colorectal carcinoma (CRC). We studied
the methylation profile in a wide region of the hMLH1 promoter and compared with the hMLH1 …

… in colorectal cancers, especially the region-specific methylation of hMLH1 promoter and its
… , expression and methylation of hMLH1 and loss of heterozygosity at hMLH1 locus in these …

… (MSI)-positive sporadic colorectal carcinomas. We studied hMLH1 promoter methylation in
… representing 29 cases of hereditary nonpolyposis colorectal cancers (HNPCCs), 28 cases …

… colon cancer, we studied the transcription and promoter methylation status of hMLH1 and
hMSH2 genes in the colon cancer cell … and hMLH1 directly through the promoter methylation in …

… hMLH1 promoter and a luciferase reporter gene, we located a proximal region of hMLH1
promoter, … We observed that in all colorectal cancer cell lines we tested, the luciferase activities …

… 15% of sporadic colorectal cancer, is usually caused by hMLH1 … the hMLH1 promoter in
hypermethylated colorectal cancer cells … (5 aza-dC), hMLH1 mRNA and protein expression were …

… colorectal cancers … the hMLH1 promoter, but also in the promoters of other genes, such as
the ER gene, N33 and MyoD.In gastric and colorectal cancers, the frequency of loss of hMLH1 …