… correlates with the loss of hMLH1 expression in primary sporadic colorectal cancer using
MSP 33 and another PCR-based approach.32, 34, 35 Hypermethylation of the …

… We report here that in colorectal cancer, inactivation of the MLH1 gene is frequently … and
the MLH1 promoter are equally common in the different clinical stages of colon cancer, which …

… The relationship between the methylation status of the hMLH1 promoter in the colorectal
cancer tissue and the disease-free survival rate did not demonstrate any statistical significance (…

… is quite common in MSI-positive endometrial and colorectal cancers. This … hMLH1 gene
inactivation and MMR deficiency. Therefore, we studied the prevalence of hMLH1 promoter …

… In addition, IVS7-212T>A, IVS11+183A>G and IVS8+719T>C of hMSH2 were associated
with the susceptibility to colon cancer rather than rectal cancer. ATTTGGGT and TCTTAGAC …

… that hypermethylation of hMLH1 might play an … hMLH1 methylation status rather than MSI
status. In this study, mutations of BRAF and KRAS and their relationship with MSI and hMLH1 …

… mutation with hMLH1 promoter methylation. … colorectal cell lines and cancers with methylated
hMLH1, whereas only 4 of 91 (4%) of the cell lines and cancers with unmethylated hMLH1 …

… is found in 15% of colorectal cancers (CRCs). Mismatch repair … germ-line mutations in the
MLH1, MSH2, MSH6, PMS2, or … of MLH1 (hypermethylation of the MLH1 gene promoter (MLH1-…

… of MLH1 protein … MLH1 promoter methylation, MLH1 protein expression, MSI and BRAF
mutations. This study is carried out within the Netherlands Cohort Study on diet and cancer …

… with hereditary non-polyposis colon cancer (HNPCC) syndrome. Here we investigate MLH1
promoter hypermethylation in 110 sporadic early-onset colorectal cancer patients. Variable …