Cytolytic activity score to assess anticancer immunity in colorectal cancer

S Narayanan, T Kawaguchi, L Yan, X Peng… - Annals of surgical …, 2018 - Springer
… in colorectal cancer (CRC). We hypothesized that since cytotoxic T cells release cytolytic
apoptotic granzymes (GZMA) to attack cancer cells, a cytolytic activity score (CYT) would be …

[HTML][HTML] Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer

A Zaravinos, C Roufas, M Nagara… - … & Clinical Cancer …, 2019 - Springer
… and genetic landscape of colorectal cancer in the context of immune cytolytic activity. By
stratifying colorectal cancer patients based on a validated cytolytic gene expression signature, …

[HTML][HTML] Evaluation of cytolytic activity and phenotypic changes of circulating blood immune cells in patients with colorectal cancer by a simple preparation of …

JC Kim, J Choi, SJ Lee, YA Lee… - Journal of the …, 2013 - synapse.koreamed.org
… This study aimed to assess the cytolytic activity and the phenotype of circulating blood
immune cells in cancer patients by using a simple preparation of peripheral blood mononuclear …

A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients

MGV Hanson, V Özenci, MCV Carlsten… - Cancer Immunology …, 2007 - Springer
… In this study, we have shown that by restoring the antioxidant status in colorectal cancer … of
vitamin E, we argue that the increased NK cytolytic activity is due to vitamin E treatment, rather …

[HTML][HTML] … dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal …

J Hänsler, TT Wissniowski, D Schuppan… - World journal of …, 2006 - ncbi.nlm.nih.gov
… , T cells were co-incubated with human CaCo colorectal cancer and HepG2 HCC cells and
… the cytolytic activity of the CD8 + and IFNγ + T cells against CaCo colorectal cancer and …

[HTML][HTML] … carcinoembryonic antigen-expression enhances the cytolytic activity of genetically-modified chimeric antigen receptor NK-92MI against colorectal cancer …

M Shiozawa, CH Chang, YC Huang, YC Chen, MS Chi… - BMC immunology, 2018 - Springer
… for predicting tumour response to chemotherapy in colorectal cancer [32]. We proposed that
… -modified NK-92MI cells in clinical therapy for terminal-stage colorectal cancer treatment. …

Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis

C Roufas, I Georgakopoulos-Soares, A Zaravinos - NAR cancer, 2021 - academic.oup.com
… promising results in metastatic dMMR/MSI-H colorectal cancer (CRC), the majority of pMMR/…
whether patients with diverse levels of immune cytolytic activity (CYT) have different patterns …

Tumor infiltrating T lymphocytes in colorectal cancer: Tumor-selective activation and cytotoxic activity in situ

M Koch, P Beckhove, J op den Winkel… - Annals of …, 2006 - journals.lww.com
… A double-staining indirect immunofluorescence technique was used for analysis of T cell
coreceptors (CD8, CD4) and T cell markers for early activation (CD69) and cytolytic activity (…

[HTML][HTML] Bispecific anti‑CD3 x anti‑HER2 antibody mediates T cell cytolytic activity to HER2‑positive colorectal cancer in vitro and in vivo

H Han, J Ma, K Zhang, W Li, C Liu… - International …, 2014 - spandidos-publications.com
Colorectal cancer (CRC) is the third most frequent cancer worldwide and a common cause
of cancer death primarily due to metastases that are resistant to conventional therapy (1). …

[HTML][HTML] Sea Anemone Heteractis crispa Actinoporin Demonstrates In Vitro Anticancer Activities and Prevents HT-29 Colorectal Cancer Cell Migration

A Kvetkina, O Malyarenko, A Pavlenko, S Dyshlovoy… - Molecules, 2020 - mdpi.com
Cytolytic activity of actinoporins was observed in different cells including platelets, fibroblasts,
parasite cells, lactotrophs and some cancer … We were able to demonstrate cytotoxic activity