Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment

S AlMusawi, M Ahmed, AS Nateri - Clinical and translational …, 2021 - Wiley Online Library
… However, before we can routinely employ colorectal cancer patient-derived explants to
model therapy response, further characterization of cellular and molecular properties and …

The tumor microenvironment in colorectal cancer therapy

L Pedrosa, F Esposito, TM Thomson, J Maurel - Cancers, 2019 - mdpi.com
… The current standard-of-care for metastatic colorectal cancer (… colorectal cancer. Here, we
review evidence of interactions between tumor angiogenesis, the immune microenvironment, …

Targeting the microenvironment in advanced colorectal cancer

DVF Tauriello, E Batlle - Trends in cancer, 2016 - cell.com
Colorectal cancer (CRC) diagnosis often occurs at late … implicating the tumor microenvironment
in CRC progression … of the microenvironment in poor-prognosis cancers. Disseminated …

The colorectal cancer immune microenvironment and approach to immunotherapies

M Koi, JM Carethers - Future Oncology, 2017 - Taylor & Francis
Colorectal cancer (CRC) is the third most common cancer in the world, with about 1.4
million cases diagnosed worldwide in 2012 [1]. The prognosis for CRC patients is largely …

The role of the tumor microenvironment in colorectal cancer and the potential therapeutic approaches

N Zafari, F Khosravi, Z Rezaee… - Journal of Clinical …, 2022 - Wiley Online Library
… proliferation, supportive tumor microenvironment, survival, and … the role of the tumor
microenvironment in the incidence of … , including colorectal cancer, microenvironment, therapeutic …

An update on colorectal cancer microenvironment, epigenetic and immunotherapy

K Jin, C Ren, Y Liu, H Lan, Z Wang - International immunopharmacology, 2020 - Elsevier
… Immunosuppressive microenvironment and immunotherapy approaches in colorectal
cancer. TAMs, Treg and MDSCs are potential druggable immunosuppressive cells that can …

Friend or foe?: The tumour microenvironment dilemma in colorectal cancer

T Colangelo, G Polcaro, L Muccillo… - … )-Reviews on Cancer, 2017 - Elsevier
… adjacent microenvironment into a pathological entity that continually evolves during cancer
… In this review, we define the biological landscape of the colorectal cancer (CRC) TME taking …

Therapeutic targets and tumor microenvironment in colorectal cancer

G Gallo, G Vescio, G De Paola… - Journal of Clinical …, 2021 - mdpi.com
… The tumor microenvironment is an important factor that affects targeted therapies for colorectal
cancer. The downregulation of the pathways activated by the components most frequently …

The effect of immune microenvironment on the progression and prognosis of colorectal cancer

J Chen, Z Chen - Medical oncology, 2014 - Springer
Cancer cells may escape from host immune responses through active suppression of the …
mechanisms in colorectal cancer remain to be elucidated. In this study, 108 colorectal tumor …

The tumor microenvironment in colorectal carcinogenesis

VG Peddareddigari, D Wang, RN DuBois - Cancer microenvironment, 2010 - Springer
… However, metastatic colorectal cancers remain incurable. Numerous agents that were … tumor
microenvironment to the progression of a number of solid tumors including colorectal cancer