… Assessment of tumor mutational burden may be useful to … more somatic mutations and higher
neoantigen burden than non-… Tumor mutational burden (TMB) is an emerging biomarker for …

… terms: (mutational burden OR mutation burden OR mutational load OR mutation load OR
TMB… ) AND (colon cancer OR colorectal cancer OR colorectal carcinoma OR colon carcinoma). …

… The Cancer Genome Atlas (TCGA) showed that 16% of colorectal cancers (CRCs)
display DNA repair mechanisms and high tumor mutational burden (TMB). Although, there is …

… across MSI-H colorectal cancers, but more importantly suggests that nearly 1 in every 33
MSS colorectal patients have an elevated mutational burden according to a classification based …

… We analyzed tumor mutation burden (TMB) from targeted next-generation sequencing data
… with colorectal cancer. TMB was defined as total number of nonsynonymous mutations per …

… In patients with metastatic colorectal cancer treated in first line, low TMB, and BRAF and
RAS mutations are negative prognostic factors. Patients with MSI-H tumors benefited more from …

… of several advanced solid cancers, in colorectal cancer, the … Tumor mutational burden (TMB)
has emerged as a potential … Here, we compiled 45 colorectal cancer studies utilizing …

Background Tumor mutational burden-high (TMB-H), which is detected with gene panel
testing, is a promising biomarker for immune checkpoint inhibitors (ICIs) in colorectal cancer (…

… We provide proof of concept that the high mutational burden and cancer neoepitope load
are the primary drivers of immune activity in CRC. In addition, our findings highlight the need to …

… As such, mutational burden determination from whole exome sequencing and … immunogenic
mutational burden. Herein, we explore the ability to quantify tumor mutational burden (TMB) …