New mechanisms and therapeutic potential of curcumin for colorectal cancer

I Villegas, S Sánchez‐Fidalgo… - Molecular nutrition & …, 2008 - Wiley Online Library
Curcumin is a polyphenol derived from Curcuma longa. Over the last few years, a number of
studies have provided evidence of its main pharmacological properties including …

[HTML][HTML] Emerging role and therapeutic potential of lncRNAs in colorectal cancer

L Schwarzmueller, O Bril, L Vermeulen, N Léveillé - Cancers, 2020 - mdpi.com
… in cancer. Because of their exceptional tissue and tumor specificity, these regulatory RNAs
represent attractive targets for cancer therapy. … to develop lncRNA-targeted cancer therapies. …

Epigenetics of colorectal cancer: biomarker and therapeutic potential

G Jung, E Hernández-Illán, L Moreira… - Nature reviews …, 2020 - nature.com
… We focus on the emerging potential for the bench-to-bedside translation of some of these …
burgeoning evidence supporting the potential of emerging epigenetic therapies in CRC as we …

[HTML][HTML] The therapeutic potential of tackling tumor-induced dendritic cell dysfunction in colorectal cancer

B Subtil, A Cambi, DVF Tauriello… - Frontiers in …, 2021 - frontiersin.org
Colorectal cancer (CRC) is the third most diagnosed malignancy and the second leading
cause of cancer-related deaths worldwide. Locally advanced and metastatic disease exhibit …

[HTML][HTML] Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer

X Cheng, X Xu, D Chen, F Zhao, W Wang - Biomedicine & …, 2019 - Elsevier
Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis. …

PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential

I Cristóbal, R Manso, R Rincón, C Caramés… - … cancer therapeutics, 2014 - AACR
… in many types of cancer. Here, we show that PP2A is frequently inactivated in patients
with colorectal cancer, indicating that PP2A represents a potential therapeutic target for this …

The therapeutic potential of targeting the BRAF mutation in patients with colorectal cancer

A Bahrami, AR Hesari, M Khazaei… - Journal of cellular …, 2018 - Wiley Online Library
… and prospective regarding the therapeutic potential of targeting BRAF mutant colorectal
mutant colorectal cancer, including trials and new potential approaches to targeted therapy. …

The therapeutic potential of MAPK/ERK inhibitors in the treatment of colorectal cancer

M Pashirzad, R Khorasanian, MM Fard… - Current Cancer Drug …, 2021 - ingentaconnect.com
… effects, supporting the therapeutic potential of these inhibitors in … pathogenesis of CRC and
the potential clinical value of synthetic … , and hence, better management of colorectal cancer. …

[HTML][HTML] Cyclin-dependent kinase inhibitors and their therapeutic potential in colorectal cancer treatment

OM Thoma, MF Neurath, MJ Waldner - Frontiers in pharmacology, 2021 - frontiersin.org
… pre-clinical studies for cancer treatment. In this review, we will focus on the therapeutic role
of various CDK inhibitors in colorectal cancer, with a special focus on the CDK4/6 inhibitors. …

Therapeutic potential of targeting Wnt/β‐catenin pathway in treatment of colorectal cancer: rational and progress

A Bahrami, F Amerizadeh… - Journal of cellular …, 2017 - Wiley Online Library
… its potential value as a therapeutic target in … therapeutic potential of targeting Wnt pathway
with particular emphasis on preclinical/clinical studies in treatment of colorectal cancer