… at inhibiting the multiple growth-promoting activities of EGFR are currently under investigation
10, 11, 12, and the results of this study indicate that colorectal tumours may represent a …

… of vascular endothelial growth factor (VEGF) and colorectal tumour progression, we have …
the tumour-development pathway from normal colon to invasive colorectal adenocarcinomas. …

… Conclusions Our findings indicate that leptin is important for CRC growth in obesity, and
acts as a growth factor for CRC at stages subsequent to tumour initiation in colorectal …

… This article will review the role of vascular endothelial growth factor (VEGF) in colon
cancer and advances in the treatment of colorectal cancer by anti-VEGF strategies. …

… The association between tumour growth factor expression … of VEGF-A in colorectal cancer
and concluded either that … and secondary sites of colorectal cancer and examine their …

… the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) …
We review the mechanisms of these pathways in tumor growth, the reagents that target them…

… is a prerequisite for tumour progression. Basic … growth factor (bFGF) and vascular endothelial
growth factor (VEGF) are angiogenic factors expressed in a broad range of human tumours. …

… At least 40% of patients with colorectal cancer develop metastases … growth factors including
transforming growth factor-β, epidermal growth factor, insulin and insulin-like growth factors (…

… step in tumour growth and progression and is regulated by tumour cell derived growth factors
that act … It has been shown that rapid exponential growth of tumours does not begin until …

… for tumours to grow beyond a minimal size 1, 2 and metastasise 3, 4, 5. Growth factors secreted
by tumour cells … Although various factors may be capable of either positively or negatively …