The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells

Q Zhou, S Wang, H Zhang, Y Lu, X Wang… - Acta Pharmacologica …, 2009 - nature.com
… In this study, apoptosis was enhanced by the combination treatment of baicalin and baicalein,
… the level of bcl-2 and upregulated the level of bax or p53 via the ERK/p38 MAPK pathway. …

Baicalin potentiates TRAIL‑induced apoptosis through p38 MAPK activation and intracellular reactive oxygen species production

L Zhang, X Wang, R Wang… - Molecular …, 2017 - spandidos-publications.com
… , the effect of combining TRAIL and baicalin was investigated … It is known that MAPKs,
including p38, serve an important … p38 MAPK was significantly activated in TRAIL and baicalin co-…

Baicalin alleviates oxidative stress and inflammation in diabetic nephropathy via Nrf2 and MAPK signaling pathway

L Ma, F Wu, Q Shao, G Chen, L Xu… - Drug design, development …, 2021 - Taylor & Francis
… Therefore, combined with our results, it was justified to conclude that BAI can act as a
natural antioxidant and anti-inflammation agent in clinical practice with high safety spectrum. …

Baicalin protects against acute pancreatitis involving JNK signaling pathway via regulating miR-15a

J Zhen, W Chen, Y Liu, X Zang - The American Journal of Chinese …, 2021 - World Scientific
… A) MAPK signaling pathway activator of Vacquinol-1 partially reversed the effect of baicalin
on JNK signaling … The effects of a TNF-alpha inhibitor and HBO combination on the severity of …

[HTML][HTML] Baicalein inhibits MMPs expression via a MAPK-dependent mechanism in chondrocytes

WP Chen, Y Xiong, PF Hu, JP Bao… - Cellular Physiology and …, 2015 - karger.com
… in chondrocytes stimulated using a mixture of IL-1β … signaling pathways are known to be
involved in cartilage degradation in OA; Of these, we focused on the MAPK signaling pathway

Baicalein attenuates renal fibrosis by inhibiting inflammation via down-regulating NF-κB and MAPK signal pathways

W Wang, P Zhou, C Xu, X Zhou, W Hu… - Journal of molecular …, 2015 - Springer
Baicalein is a natural flavonoid that possesses notable anti-inflammatory effects. In this study,
we detected whether baicaleinBaicalein treatment significantly attenuated tubulointerstitial …

The comparative study of the therapeutic effects and mechanism of baicalin, baicalein, and their combination on ulcerative colitis rat

S Liang, X Deng, L Lei, Y Zheng, J Ai, L Chen… - Frontiers in …, 2019 - frontiersin.org
baicalin, baicalein, or a combination of the two. Results: The results showed significant
differences in the therapeutic effects of baicalin, baicalein, and the combinationMAPK pathways. …

[HTML][HTML] Baicalin augments hyperthermia-induced apoptosis in U937 cells and modulates the MAPK pathway via ROS generation

SA Zakki, ZG Cui, L Sun, QW Feng, ML Li… - Cellular Physiology and …, 2018 - karger.com
Baicalin in combination with hyperthermia markedly enhanced apoptosis and reduced the
viability of U937 cells. A: U937 cells were treated with BCN (10–100 µM) and incubated for 6 h…

Baicalin mediated regulation of key signaling pathways in cancer

S Singh, A Meena, S Luqman - Pharmacological research, 2021 - Elsevier
… mechanism of action and affected signaling pathways in different types of cancer. Additionally,
we also shed some light on the combination of baicalin with conventional drugs along …

Baicalin suppresses migration, invasion and metastasis of breast cancer via p38MAPK signaling pathway

XF Wang, QM Zhou, J Du, H Zhang… - Anti-Cancer Agents in …, 2013 - ingentaconnect.com
MAPK pathways for cancer invasion and metastasis. In this study, we showed that baicalin
decreased the level of activationrequired p38 MAPK … and combined treatment of baicalin and …