… We discovered that pathway reactivation in RAS mutant models occurs at the level of CRAF
… clear pathway reactivation, we next examined effects of combining MEK and ERK inhibition. …

… evade MEK inhibition, and this often involves a re-wiring of the MAPK pathway to reactivate
… by which they can promote cell signaling, and reactivation of RTKs following MEK inhibition …

… that reactivate the RAF/MEK/ERK pathway (4–6) led to the hypothesis that addition of a …
outcomes of combined BRAF and MEK inhibition and frequent reactivation of RAF/MEK/ERK …

… (MAPK) pathway with combined BRAF and MEK inhibition was … the BRAF inhibitor dabrafenib
combined with the MEK inhibitor … The phase III study of this combination versus dabrafenib (…

… gavage daily suppressed MAPK pathway more effectively and … alone, combined BRAF V600E
and MEK inhibitor treatment … corresponding to sustained MAPK pathway inhibition. Results …

… These include reactivation of the MAPK pathway resulting in … of the FAK pathway, both
alone and in combination with MEK … of resistance to BRAF/MEK inhibition (www.clinicaltrials.gov; …

… pathway reactivation in a large panel (n = 34) of KRAS-mutant cell lines, by measuring the
reduction of phospho-MEK … We also found that combining SHP2 and MEK inhibitors led to …

… , allowing reactivation of ERK. Thus, MEK2 selectively escapes inhibition by allosteric … site
inhibitors suggests that MEK inhibitors will need to be used in combination with other inhibitors…

… MEK inhibitors in combination can override resistance to single agents 15 . We therefore
reasoned that combined RAF/MEK … to AZD6244 or CI-1040 in combination with PLX470 (1 μM …

… in part through reactivation of MAPK pathway. Intriguingly, … redundantly reactivate RAS–MAPK
and combined upstream … FGFR inhibition combined with downstream blockade of MEK …