… for the evaluation of upfront combination MEK and RET TKI … , upfront combination ALK/MEK
or EGFR/MEK inhibition has … inhibition via reactivation of the RAS/MAPK pathway via the …

… used three RB-reactivating agents; the MEK inhibitor trametinib/… to reactivate RB function by
inhibiting the PI3K-Akt pathway.… combined treatment of 5-FU and RB-reactivating agents, RB-…

… inhibition and cause resistance by pathway reactivation [32,37]. … of MEK inhibition has
triggered various clinical trials using MAPK pathway inhibitors in combination with PI3K pathway …

… MEK proteins with overexpressed BRAF, which consequently initiates reactivation of the
MAPK pathway [… and ERK reactivation by feedback mechanisms, the combination of αC-IN-RAF …

… MEKi–evoked ERK MAPK pathway reactivation. A and B, … combined MEK/SHP2 inhibition
blocks cell proliferation and promotes shrinkage of tumors with increased RAS/ERK pathway …

… a rational combination approach that inhibits inhibitor-induced pathway reactivation and can
… We hypothesized that RTK reactivation in response to short-term and long-term exposure to …

… The 22RV1 prostate cancer cell line possesses activation of the MEK/ERK pathway [23], …
on the AKT pathway [24]. We demonstrate that combination blockade of the AKT and MEK does …

… pathway and their sensitivity to a selective inhibitor of ERK1/2. … MEK-R cell lines described
in this study with a combination … progressed on MEK inhibitor therapy and show reactivation of …

… pathway reactivation leads to resistance to vemurafenib in BRAF-mutant colorectal cancers
and that combined … approach [eg, combined RAF/MEK inhibition (Supplementary Fig. S1), …

… resistance mechanisms to BRAF and MEK inhibition. In this … Dabrafenib in combination with
trametinib versus dabrafenib … kinase blocked the pathway reactivation induced by the ligand …