… a rational combination approach that inhibits inhibitor-induced pathway reactivation and can
… We hypothesized that RTK reactivation in response to short-term and long-term exposure to …

… inhibitor alleviated the side effects by inhibiting the reactivated MAPK. However, resistance
also occurs in patients after a period of treatment with BRAF/MEK combination therapy. …

… pathway and their sensitivity to a selective inhibitor of ERK1/2. … MEK-R cell lines described
in this study with a combination … progressed on MEK inhibitor therapy and show reactivation of …

… (MEK) inhibitor [169]. This downstream inhibition of the pathway reduces possibilities for ERK
reactivation… As of May 2019, the FDA has approved a total of three BRAF/MEK combination …

… reactivation of MEK in MEKi resistant cell lines after MEK inhibition. Model analysis suggested
that combining MEK … of an upstream node prevents pathway reactivation. Based on our …

… Here we show that combined treatment with MEK and ERK inhibitors blocks the emergence
… by ERK reactivation, thereby suggesting that concurrent inhibition of the pathway at multiple …

… combination with a MEK inhibitor (30). An additional benefit of the BRAF plus MEK inhibitor
combination … In summary, resistance to vemurafenib frequently occurs through reactivation of …

… with a combination of AZD0424 and a MEK inhibitor blocked the activation of EGFR, SHP2,
PLCγ suggesting that reactivation of signalling through the EGFR pathway in response to …

… Combined treatment with a MEK inhibitor prevented BRAF inhibitor–induced metastasis in
… of MEK-ERK pathway activation, we treated the mice with PLX4720 and the MEK inhibitor …

Mitogen-Activated Protein Kinase (MAPK) pathway activation … resulted in decreased MEK
and ERK phosphorylation and … , dabrafenib also induced MAPK pathway activation in wild-…