… In this study of KRAS-mutant lung cancer models, combining MEK inhibition with
immunotherapies such as anti-PD-1 or anti-PD-L1 antibodies showed a synergistic effect and …

… more effective inhibitory effects, the strategy of combination therapy … idea of combining a
BRAF inhibitor with a MEK inhibitor has … Interestingly, this regimen resulted in superior inhibitory …

… the mechanisms of resistance to combined BRAF and MEK inhibition. Because the combination
of BRAF and MEK inhibition may more effectively inhibit RAF/MEK/ERK signaling one …

… Dabrafenib and trametinib were in the first BRAF and MEK inhibitor combination in clinical
trials, and currently the FDA approved combination in patients with advanced BRAFV600 …

… Given that the combination of a pan-RAF inhibitor and a MEK inhibitor could drive a profound
response, we sought to establish what factors were responsible for this. Accordingly, we …

… MEK inhibition in the NRAS and KRAS mutant setting [27–29]. Together these findings indicate
that in the context of MEK inhibition… the combination of MEK inhibitors with ERK inhibitors …

… (MEK) inhibition. We hypothesized that treating this patient with combined therapy with RAF
and MEK inhibitors … that combined therapy with vemurafenib and the MEK inhibitor GDC-…

… are currently evaluating the combination of PI3K and MEK inhibitors in a … /RAF/MEK/ERK
pathways, the cross-talk between them, and the current generation of PI3K and MEK inhibitors …

… only by RAF/MEK combinatorial blockade. Combined RAF-MEK Inhibition Shows Synergy
in … Mutations We tested whether combined RAF and MEK inhibition could be effective also in …

… resistance, combination therapy targeting BRAF and MEK, a … BRAF and MEK inhibitor
combinations have been approved … for various BRAF plus MEK combination regimens in three …