… P124L allele in resistance to MEK inhibition, we examined the effects of MEK inhibition on ex
vivo … In this study, we used a systematic approach that combined random mutagenesis and …

… combined B-RAF/AurkA inhibition for B-RAF mutated melanomas and MEK/AurkA inhibitor
combination for patients without B-RAF … RAF, MEK and AurkA inhibitor triple drug combination …

… type II RAF inhibitors and a MEK inhibitor led to a stronger ERK pathway inhibition and growth
… with CRAF oncogene dependency to the combination of type II RAF and MEK inhibition. …

… We observed enhanced antitumor efficacy for RAF dimer and MEK inhibitor combination, …
reports suggesting RAF dimer or pan-RAF inhibitor in combination with MEK inhibitor may be a …

… Thus, the ability of mutant RAS to suppress FOXO3a and its reversal by MEK inhibitors … and
MEK inhibitors in RAS mutant tumors. The rational combination of PARP and MEK inhibitors …

… targeting of BRAF and its downstream target MAPK/ERK kinase (MEK) may … of combination
BRAF and MEK inhibition, we generated melanoma cell clones resistant to the BRAF inhibitor …

… Our study suggests that dual MAPK pathway blockade with the BRAF inhibitor dabrafenib
and the MEK inhibitor trametinib can lead to meaningful clinical benefit in a subset of patients …

… of each pathway individually, a recent study combined PD0325901 with a dual PI3K and
mTOR inhibitor, PF-04691502, in a multiarm phase I study; 71 however, toxic effects precluded …

… A rationally designed combination of RAF and MEK inhibitors based on their conformation
selectivity achieved increased efficacy and a high therapeutic index when used to target …

… RAF activation in response to MEK inhibition [27] … combined MEK and RAF inhibition provide
unequivocal evidence of a striking pro-apoptotic synergism of such a “vertical” combination …