… combined BRAF and MEK inhibition is more effective in BRAF V600 -mutant melanoma than
single-agent BRAF inhibitors. … in patients who had received prior BRAF inhibitor treatment. …

… of one such combination, trametinib (MEK inhibitor) with afuresertib (AKT inhibitor). … events
and pneumonitis (all considered class effect with MEK inhibitors) [13] and GI-related events (…

… combining AZD6244 with mTOR inhibitor AZD8055 should be similarly synergistic to combining
AKT and MEK inhibition… the CCA cells lines after combined treatment with AZD6244 and …

… The MEK inhibitors in combination with other kinase/mutant gene inhibitors have shown …
Various researches have shown that ERK inhibitors in combination with MEK inhibitors …

… inhibitor, may optimize MAPK pathway suppression and … of combined BRAF and EGFR
inhibition, combined MEK and EGFR inhibition, and combined BRAF, EGFR, and MEK inhibition …

… of a concomitant triple-therapy combination of BRAF and MEK inhibitors with anti-PD-1 in …
1 trial, a combination of approved doses of the BRAF inhibitor dabrafenib, the MEK inhibitor …

… with RAF and MEK inhibitors in patients with primary brain tumors and describe ongoing
clinical trials of RAF inhibitors in … this, RAF inhibitors have been combined with MEK inhibitors in …

… Moreover, MEK inhibitors can arrest cancer cells in G 1 phase and repress prosurvival Bcl2
… of the combination of MEK inhibitors with cytotoxic agents or other targeted inhibitors. A …

… We next explored combined Raf and Mek inhibition using SFN and AZD6244 in a mouse
orthotopic xenograft model. MDA-MB-231 cells were engrafted into mammary glands of BALB/c …

… novel combination treatment with HSP90α/β inhibitor and RAS-RAF-MEK-ERK signaling
pathway inhibitors … that the combination of RAF inhibitors and MEK inhibitors shows significant …