… In addition, combination BRAF/MEK inhibitor trials have improved our understanding of the
mechanistic basis for acquired resistance in metastatic melanoma through characterization of …

… inhibitors which in vitro efficiently block the activation of RAF … the double blockade of both
MEK and RAF could be more effective … shown the combined treatment with a MEK inhibitor plus …

… is CRAF-dependent and can be abrogated by MEK inhibition. Furthermore, we demonstrate
that co-administration of BRAF and MEK inhibitors improves both the safety, by reducing the …

… It was therefore suggested that BRAF/MEK-targeted therapy … BRAF-mutated melanoma,
combined BRAF/MEK and PD-1 … the efficacy of the combination of BRAF/MEK inhibitor (BRAF/…

… combination induced more complete responses than vemurafenib alone (10% versus 4%).
The combination … and colleagues, the RAF/MEK inhibitor combination was associated with …

… , combination BRAF inhibition and MEK inhibition therapy when compared to BRAF inhibition
… Combination therapies of encorafenib plus binimetinib, dabrafenib plus trametinib, and …

… responses to combination BRAF and MEK inhibitor treatment. We … NRAS predict sensitivity
to MEK inhibition in melanoma. We … in response to combination BRAF and MEK inhibition, but …

… a combination of a BRAF inhibitor and a MEK inhibitor have … the fact that combined BRAF
and MEK inhibition are increasingly … of combined BRAF and MEK inhibition versus the BRAF …

… of the combination of BRAF plus MEK inhibitors compared with BRAF inhibitor monotherapy
… evidence for the mechanisms of resistance to combined therapy and assess future treatment …

… Furthermore, combining a RAF and a MEK inhibitor upfront may be a rational strategy as
the addition of a MEK inhibitor may attenuate the adverse effects of the RAF inhibitor while …