… to RAF and MEK inhibitor therapy [57]. Combined YAP and RAF or MEK inhibition was …
a biomarker of worse initial response to RAF and MEK inhibition in patients, indicating the …

… inhibitor inhibited the proliferation of LGSOC cells In light of the early promising data on the
use of MEK inhibitors in … to confirm the effects of combining these drugs with metformin in a …

… of the Ras-Raf-MEK-ERK pathway. Administration of a MEK inhibitor alone failed to provide
… Therefore, we combined an HDAC inhibitor with a MEK inhibitor, which had a synergistic …

… New evidence suggests that the combination of BRAF and MEK inhibitors … ) and MEK (trametinib)
inhibitors as well as the available data on BRAF inhibitor + MEK inhibitor combination …

… Together, our results indicate that the combination of Raf and MEK inhibition could be a
potential therapeutic strategy not only to enhance clinical efficacy but also to bypass or prevent …

… resistance and the RAF–MEK–ERK pathway contributes to mTOR activity, … combination
of BRAF or MEK inhibitors with a PI3K/mTOR inhibitor may overcome acquired BRAF inhibitor …

… following kinase inhibition. MoDC cross-… combined inhibition of MEK and BRAF. The results
of this study demonstrate that MEK inhibition, alone or in combination with BRAF inhibition, …

… the effectiveness of combined BRAF and MEK inhibition with PFS, ORR, and OS. Currently,
the network meta-analysis supports the combined BRAF and MEK inhibition is the preferred …

… received either RAF inhibitor or combined RAF/MEK inhibitor. The latter combination has …
survival in mutant BRAF melanoma patients compared with RAF inhibitor alone (37). Three out …

… As assessed by IP/WB, both RAF inhibitors caused … RAF and MEK inhibition in BRAF-wt/RAS-Mut
contexts We then analyzed the functional effects of combined BRAF and MEK inhibition …