… Our results provide evidence that mTOR inhibitor in combination with BRAF and MEK
inhibitors blocked the growth of CR melanoma cells primarily due to cell cycle arrest. Targeting …

… , 3 have had a prior MEK inhibitor and are currently are on … of the combination of a RAF-MEK
and FAK inhibitor with very … those who had been previously treated with a MEK inhibitor. …

… with a focus on MEK inhibitors. Then, the activation of feedback networks accompanying
MEK inhibition is briefly reviewed. Combination strategies that involve the simultaneous …

… However, further researches need to be conducted to indicate how we can combine other
drugs with MEK inhibitors to significantly increase therapeutic effects on patients with lung …

… underlie resistance to combined BRAF and MEK inhibition. As most patients with metastatic
BRAF-V600E mutant melanoma will be treated with BRAF and MEK inhibitors, delineating …

… In the present study, we assess the effects of MEK inhibitors AZD6244 on the JAK2-STAT3 …
the effects of the combination of MEK inhibitor and the JAK2-STAT3 pathway inhibition for the …

… Herein, we found that inhibition of the kinase ERK2 increases the response to sorafenib
in liver cancer. Our data indicate that a combination of sorafenib and a MEK inhibitor is most …

… to examine whether combining the EPE peptide with the MEK inhibitor trametinib, would
overcome the resistance to the EPE peptide. Indeed, combined inhibition of MEK and ERK …

… The aim of our study was to investigate the effect of pan-RAF inhibitors (sorafenib and AZ628)
and MEK inhibitor (selumetinib) combination treatment on non-V600 BRAF mutant tumor …

… -specific BRAF inhibitors in combination with MEK inhibitors, which … that BRAF inhibitors
amplify the effects of MEK inhibitors in … a BRAF and MEK inhibitor combination with superior anti-…