… Thrombocytopenia, not commonly seen with MEK inhibition, … A preclinical study of selumetinib,
another MEK inhibitor, plus … synergy when MEK inhibitors are combined with gemcitabine …

… Hence, combined BRAF and MEK inhibitor therapy is an attractive strategy to delay or …
the superiority of combination BRAF and MEK inhibition over BRAF inhibition alone: COMBI-d (…

… MEK inhibitor to a BRAF inhibitor improves the blockade of the mitogen-activated protein
kinase pathway. The combination of dabrafenib with the MEK inhibitor … a BRAF inhibitor alone. …

… sensitive to MEK inhibition, we characterized their response to two different MEK inhibitors.
… , but only D04 cells were particularly sensitive to MEK inhibition (Fig. 2 and Tables S3 and S4)…

… with BRAF inhibitor monotherapy and BRAF plus MEK inhibitor combination therapy in …
”, “dabrafenib”, and “vemurafenib” in combination with “rechallenge” and “melanoma”. We …

… the efficacy and safety of combined BRAF/MEK inhibition, using encorafenib and binimetinib,
… This is the first prospective clinical trial to demonstrate that combined BRAF/MEK inhibition …

… dimers and results in adaptive resistance to RAF inhibitors (16). Improved efficacy is seen
with combined RAF and MEK inhibitors, as MEK inhibition can suppress the resultant ERK …

… Given the results above, we hypothesized that the combination of BRAF and MEK inhibitors
… To investigate whether the combination of BRAF V600E and MEK inhibitors could reduce …

… However, a combination of PKC and MEK inhibition led to sustained MAPK pathway inhibition
… discuss the use of a combination of PKC and MEK inhibitors for the treatment of GNAQ/…

… Treatment with the selective MEK inhibitor binimetinib as a single agent or in combination
with RAF inhibitors induced transient retinopathy with multiple bilateral lesions in some …