… Treatment with the selective MEK inhibitor binimetinib as a single agent or in combination
with RAF inhibitors induced transient retinopathy with multiple bilateral lesions in some …

… is the inhibition of parallel … of MEK and ERK in HCC cells at low concentrations of sorafenib
due to paradoxical activation of RAF signaling (13) argues that dual inhibition by combining …

… to either combined RAF/EGFR or RAF/MEK inhibition. … resistance to combined RAF/EGFR
and RAF/MEK inhibition. A… to combined RAF/EGFR inhibition (VACO-RE) or RAF/MEK …

… to BRAF inhibitors, alone or in combination with MEK inhibitors, … Using the HSP90 inhibitor
AT13387, which is currently in … BRAF inhibitors alone or to a BRAF/MEK inhibitor combination. …

… midostaurin and the MDM2-inhibitor HDM201 [… MEK inhibitor cobimetinib and the
MDM2-inhibitor idasanutlin [21]. Here we found that the MCL1-inhibitor S63845 and the …

… by MEK inhibitors, we hypothesize that the combined treatment with STAT3 and MEK inhibitors
… pancreatic cancer and colon cancer cells compared with MEK or STAT3 inhibitor alone. …

… by MEK inhibitors and enhances sensitivity of KRAS-dependent cancers to MEK inhibition, …
Our data provide strong evidence that combined SOS1 and MEK inhibition represents an …

… The particular combination of phosphoinositide 3-kinase or phosphatidylinositol-3 kinase
(PI3K) and MEK inhibitors is generally being evaluated in several clinical studies in various …

… Thus, we tested whether combination therapy targeting both Raf-1 and MEK was able to …
Our findings have shown that simultaneous Raf-1 RNAi and pharmacological MEK inhibition …

… trial evaluated the combination of the MEK inhibitor selumetinib (AZD6244) with chemotherapy.
Unfortunately, no additional benefit was observed for the combination of selumetinib and …