[HTML][HTML] Magnitude of umeclidinium/vilanterol lung function effect depends on monotherapy responses: results from two randomised controlled trials

JF Donohue, D Singh, C Munzu, S Kilbride… - Respiratory …, 2016 - Elsevier
… to dual bronchodilator therapy is currently unknown. We aimed to investigate whether dual
therapy with … We conducted two, three-way, complete block cross-over studies, comparing the …

Extended therapy with ipratropium is associated with improved lung function in patients with COPD: a retrospective analysis of data from seven clinical trials

SI Rennard, CW Serby, M Ghafouri, PA Johnson… - Chest, 1996 - Elsevier
… The magnitude of the benefits observed in the current study is small. Small improvements in
… benefit from long-term bronchodilator therapy. The comparison group in the present study …

Interpretation of bronchodilator response in patients with obstructive airways disease. The Dutch Chronic Non-Specific Lung Disease (CNSLD) Study Group.

PL Brand, PH Quanjer, DS Postma, HA Kerstjens… - Thorax, 1992 - thorax.bmj.com
… To allow comparison of different measures of bronchodilator … for all measures of bronchodilator
response except A FEV1 % [pred … airway obstruction, the magnitude of the bronchodilator

New combination bronchodilators for chronic obstructive pulmonary disease: current evidence and future perspectives

D Singh - British Journal of Clinical Pharmacology, 2015 - Wiley Online Library
… is well known that the magnitude of bronchodilation with the same … comparisons of dual
bronchodilators with ICS/LABA. Although the GOLD guidelines include LABA plus LAMA therapy

[HTML][HTML] Impact of prior and concurrent medication on exacerbation risk with long-acting bronchodilators in chronic obstructive pulmonary disease: a post hoc analysis

I Naya, L Tombs, DA Lipson, I Boucot, C Compton - Respiratory research, 2019 - Springer
bronchodilator type versus PBO, and to explore the inter-dependency of lung function
improvement and the magnitude … exacerbation trials comparing these bronchodilator classes to …

The MABA approach: a new option to improve bronchodilator therapy

M Cazzola, JL Lopez-Campos… - European Respiratory …, 2013 - Eur Respiratory Soc
magnitude. All the above features make us believe that GSK961081 may represent a real
advance in bronchodilator therapy … In particular, a long-term comparison with a once a day …

A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol

JF Donohue, JA van Noord, ED Bateman, SJ Langley… - Chest, 2002 - Elsevier
Bronchodilator therapy has been advanced with the introduction of more convenient dosing
for theophyllines, new devices for inhaled therapy… , magnitude of task, and magnitude of effort…

Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis

L Hartling, RM Fernandes, L Bialy, A Milne, D Johnson… - Bmj, 2011 - bmj.com
bronchodilators given with and without steroids. By carrying out mixed treatment comparisons
compared with placebo and bronchodilators showed a similar magnitude of effect (32%) …

Bronchodilator responsiveness using spirometry in healthy and asthmatic preschool children

LM Borrego, J Stocks, I Almeida, S Stanojevic… - Archives of disease in …, 2013 - adc.bmj.com
… CR w is conventionally assessed by comparing the relative difference between … magnitude
of BDR response: that is, a 9% threshold was previously reported for positive bronchodilation, …

… and safety of LAMA/LABA fixed-dose combination therapies in chronic obstructive pulmonary disease: a systematic review of direct and indirect treatment comparisons

JR Hurst, K Gruffydd-Jones, M Biswas… - … Journal of Chronic …, 2020 - Taylor & Francis
… combination therapy may be delivered via a separate inhaler for each bronchodilator
component… At 24 weeks, the magnitude of the effect of the change from baseline in peak FEV 1 …