… β-chain subunit (β146His) participates in two electrostatic interactions in the deoxy (T) state.
… one another, outside the range of electrostatic interaction. The consequent rupturing of the …

… tendency to occur within the range of electrostatic interaction around the slightly DMs, …
mutations predominantly occur within electrostatic interaction ranges of the destabilizing mutations…

… electrostatic interactions, either between carboxylate groups (TMV) or histidine side-chains
(FMDV) belonging to different subunits, may provide a switching mechanism for controlling …

… sufficient to enable the respective IN mutants to bind gRNA, and … highly pliable electrostatic
interactions in IN-gRNA binding. … If IN-gRNA binding is mediated by electrostatic interactions, …

… but rather its stability with the compensatory mutations providing the compensatory increase
in … The study of recent virus evolution revealed other examples of compensatory interactions, …

… of compensatory epistasis can alleviate the mutations’ … but the interacting residue(s) postulated
to play a compensatory role … of Lys270 via long-range electrostatic interactions or from the …

… that electrostatic and/or non-electrostatic interactions … mutations in P4 binding, we created
three additional mutants – each with a lysine mutation in place of the arginine mutation …

… that specific, pairwise electrostatic interactions at the interface … this region and the network
of interacting ionic residues that are … Furthermore, we show that representative mutations in the …

… Permissive compensatory mutations facilitate protein evolution, since … compensatory
interactions are important since they may result in variable penetrance of pathogenic mutations or …

… We postulate that there may be common regional mechanisms affecting critical interhelical
interactions that lead to misfolding. Using compensatory mutations (based upon crystal …