The complex landscape of pancreatic cancer metabolism

CM Sousa, AC Kimmelman - Carcinogenesis, 2014 - academic.oup.com
… pathogenesis of this tumor, oncogenic Kras plays a critical role in much of the metabolic
reprogramming seen in PDA. In this review, we discuss the metabolic landscape of PDA tumors, …

[HTML][HTML] Decoding the Intricate Landscape of Pancreatic Cancer: Insights into Tumor Biology, Microenvironment, and Therapeutic Interventions

A Argentiero, A Andriano, IC Caradonna, G de Martino… - Cancers, 2024 - mdpi.com
… ductal adenocarcinoma (PDAC) is an aggressive malignancy with a complex tumor
cancer metabolism, this acidic environment is largely induced by the secretion of metabolic end …

Defining a metabolic landscape of tumours: genome meets metabolism

C Seth Nanda, SV Venkateswaran, N Patani… - … journal of cancer, 2020 - nature.com
… understanding of cancer metabolic reprogramming, and the role of metabolic dysregulation
in … Some examples that highlight the intricacies of a complex genomic–metabolic landscape

Targeting the metabolic rewiring in pancreatic cancer and its tumor microenvironment

K Yamamoto, D Iwadate, H Kato, Y Nakai, K Tateishi… - Cancers, 2022 - mdpi.com
cancer are complicatedmetabolic demands of highly proliferative cancer cells, while the
homeostatic role, mainly mediated by selective autophagy, prevents the development of cancer

The intricate metabolism of pancreatic cancers

F Camelo, A Le - The Heterogeneity of Cancer Metabolism, 2018 - Springer
… This chapter will discuss the complexity of metabolic features in pancreatic cancers. … cancer
metabolism, we need to take into account the close relationship between cancer metabolism

[HTML][HTML] Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment

M Zuzčák, J Trnka - International Journal of Oncology, 2022 - spandidos-publications.com
… PC, a disease with a multifaceted and often transient metabolic landscape. In addition, the
… -cell level is also possible via a complex metabolic profiling method single cell energetic …

Harnessing metabolic dependencies in pancreatic cancers

J Encarnación-Rosado, AC Kimmelman - … Reviews Gastroenterology & …, 2021 - nature.com
… of metabolism in pancreatic cancer: central carbon metabolism … mechanisms and metabolic
crosstalk in the complex TME. … targeting metabolic dependencies in pancreatic cancers. …

Pancreatic cancer metabolism: breaking it down to build it back up

RM Perera, N Bardeesy - Cancer discovery, 2015 - AACR
… In addition, the interplay between evolving PDA and whole-body metabolism contributes to
… in tumor cell and systemic metabolism are central to the biology of pancreatic cancer. Further …

Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape

G Rinaldi, M Rossi, SM Fendt - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
… In conclusion, identifying and understanding complex metabolic interactions is a basis for …
are limited in the pancreatic tumor microenvironment.68, 69 Likewise, both ovarian and breast …

Exploring the metabolic landscape of pancreatic ductal adenocarcinoma cells using genome-scale metabolic modeling

MM Islam, A Goertzen, PK Singh, R Saha - Iscience, 2022 - cell.com
… Rewired glucose, amino acid, and lipid metabolism and metabolic crosstalk within the tumor
… unlimited pancreatic tumor progression. The metabolic alterations of pancreatic cancer are …