过去一年中添加的文章,按日期排序

Abstract PR014: Combinatorial genetic screens to map synthetic lethal interactions and identify new cancer drug targets in KRAS mutant cancers

R Arafeh, L Chang, L Sawyer, H Wang… - Molecular Cancer …, 2024 - AACR
27 天前 - … This landscape of genetic interaction network of yeast has … , making this very complex
network impossible to screen … KRAS mutant cancers (lung, pancreas and colon cancers). …

Mapping the Metabolic Landscape of the Healthy Human Pancreas and the Pancreatic Tumor Microenvironment

M Bonilla - 2024 - deepblue.lib.umich.edu
42 天前 - … Detecting pancreatic cancer is difficult, as symptom presentation is rare and
generalizable to a variety of diseases, thus detection and diagnosis occurs when a patient already …

Collagen Lattice Model, Populated with Heterogeneous Cancer-Associated Fibroblasts, Facilitates Advanced Reconstruction of Pancreatic Cancer Microenvironment

X Song, Y Nihashi, Y Imai, N Mori, N Kagaya… - International Journal of …, 2024 - mdpi.com
102 天前 - … To enhance the treatment landscape of PDAC, a 3D … platform mirrors complex
tumor microenvironmental … Our RNA-seq analysis indicated marked alterations in the metabolic

Adaptations in cancer: a molecular and mechanistic rewiring

R Ghose - 2024 - repositori.upf.edu
107 天前 - Cancer cells are constantly subject to complex stresses in the tumour … stress on
cancer cells and how subcellular mitochondria redistribution leads to important metabolic and …

[HTML][HTML] … prediction model and analysis of immune microenvironment landscape at single-cell level in pancreatic adenocarcinoma: a tumor marker prognostic study

Z Xu, J Li, Z Cao, H Xu, Y Ying, Z Xu, R Liu… - … Journal of Surgery, 2024 - journals.lww.com
111 天前 - … location, making tumor tissue acquisition difficult. This … basic translational research
of pancreatic cancer surgery. … Our research identified pyrimidine metabolism as a key …

[HTML][HTML] Advances in Drug Therapy for Metastatic Pancreatic Ductal Adenocarcinoma

J Gao, J Wang, C Guan, W Shi, Q Dong, J Sheng… - … of Cancer, 2024 - ncbi.nlm.nih.gov
133 天前 - … the molecular signature and immune landscape of PDAC has … diagnosed with
progressive pancreatic cancer at an early … and nucleic acid metabolism provides tumor cells with …

[HTML][HTML] Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lens

H Chi, L Su, Y Yan, X Gu, K Su, H Li, L Yu… - Frontiers in …, 2024 - frontiersin.org
142 天前 - … into the complex interplay between mitochondrial gene defects and pancreatic
cancer … alter the metabolic landscape of the pancreatic cancer tumor microenvironment (13, 18)…

Crosstalk between metabolic remodeling and epigenetic reprogramming: A new perspective on pancreatic cancer

J Ren, B Ren, X Liu, M Cui, Y Fang, X Wang, F Zhou… - Cancer Letters, 2024 - Elsevier
156 天前 - pancreatic cancer is critical for identifying targets for diagnosis and treatment. Two
important hallmarks of cancermetabolic … , creating a complex interaction landscape that is …

[HTML][HTML] Semaglutide and beyond: a turning point in obesity pharmacotherapy

TLR Health–Europe - The Lancet Regional Health-Europe, 2024 - ncbi.nlm.nih.gov
158 天前 - … in the complex landscape of obesity pharmacotherapy. … , Parkinson's disease, and
metabolic dysfunction-associated … certain cancers, particularly thyroid and pancreatic cancer, …

Abstract B026: Dissecting the pancreatic cancer microenvironment using landscape ecology

MD Toruner, L Cisneros, Z Siddiqui, C Meroueh… - Cancer Research, 2024 - AACR
158 天前 - Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second cause of
cancer death in the US by 2040. Five-year overall survival is only ~12% despite decades of …