Genetic toxicity of complex mixtures of polycyclic aromatic hydrocarbons: evaluating dose-additivity in a transgenic mouse model

AS Long, CL Lemieux, R Gagné… - … science & technology, 2017 - ACS Publications
… the complex mixtures studied, we compared the complex mixture results to results obtained
with synthetic mixtures only … Additionally, in order to examine the PEF-M for PAH mixtures, we …

Mixture toxicity and gene inductions: can we predict the outcome?

F Dardenne, I Nobels, W De Coen… - … and Chemistry: An …, 2008 - Wiley Online Library
Mixture toxicity is a complex issue and remains poorly understood. This is illustrated … Mixture
toxicity can be influenced by different interactions of the compounds composing the mixture

Utility of short-term tests for genetic toxicity

DM DeMarini, J Lewtas, HE Brockman - Cell biology and toxicology, 1989 - Springer
… By definition, short-term tests (STTs) for genetic toxicity detect genotoxic agents, … complex
mixtures as well as the antimutagenic effects of various pure compounds and complex mixtures

Genetic toxicity of a mixture of fifteen pesticides commonly found in the Italian diet

P Dolara, A Vezzani, G Caderni, C Coppi… - Cell biology and …, 1993 - Springer
… To determine the toxicological effects of complex mixtures of pesticides, we obtained data
on 100 pesticide residues in common foods of central Italy. Fifteen pesticides were more …

A Panel of Quantitative Calux® Reporter Gene Assays for Reliable High‐Throughput Toxicity Screening of Chemicals and Complex Mixtures

B van der Burg, S van der Linden… - … methods in toxicity …, 2013 - Wiley Online Library
… of toxicity of new chemicals and pharmaceuticals, either alone or in complex mixtures as …
used chemicals alone, not to speak of the complex mixtures we are exposed to. A major reason …

The genotoxicity of priority polycyclic aromatic hydrocarbons in complex mixtures

PA White - … Research/Genetic Toxicology and Environmental …, 2002 - Elsevier
… ) substances in complex mixtures. Lack of information about the behavior of toxic substances
in complex mixtures is often avoided by assuming that the toxicity of a mixture is simply the …

Modeling the toxicity of pollutants mixtures for risk assessment: a review

M Sigurnjak Bureš, M Cvetnić, M Miloloža… - Environmental chemistry …, 2021 - Springer
… numerical methods such as genetic algorithm, neural networks, … mixture toxicity and clarify
the interaction between mixture components. The risk assessment of mixtures is a complex

Environmental complex mixture toxicity assessment.

HS Gardner Jr, LM Brennan… - Environmental …, 1998 - ehp.niehs.nih.gov
… characterized as a mixture scenario. The use of bioassays to assess mixtures of complex
environmental chemical contaminants has involved both in vitro genetic toxicity assays as well …

Complex mixtures: Methods for in vivo toxicity testing

, … for the In Vivo Toxicity Testing of Complex Mixtures - 1988 - books.google.com
… the toxicity of simple mixtures, particularly binary mixtures. … in permitting the extrapolation of
toxicity to lower doses. Although … in assessing the toxicity of more complex mixtures, it is clear …

[PDF][PDF] Environmental toxicity of complex chemical mixtures

AM Gillespie - 2010 - core.ac.uk
… A variety of technologies, including molecular biology, chemistry, and genetics have …
complex mixture toxicity. Studies were conducted to measure the genotoxicity of complex mixtures