Molecular genetic studies of complex phenotypes

AJ Marian - Translational Research, 2012 - Elsevier
… Thus, a complex phenotype is the consequence of complex interactions of a large number
of genetic and nongenetic determining factors (Fig 1). The review focuses primarily on the …

[HTML][HTML] The molecular genetics and neurobiology of developmental dyslexia as model of a complex phenotype

J Kere - Biochemical and biophysical research communications, 2014 - Elsevier
Among complex disorders, those concerning neuropsychiatric phenotypes involve particular
challenges compared to disorders with more easily distinguished clinical signs and …

Clinical phenotypes and molecular genetic mechanisms of Carney complex

D Wilkes, DA McDermott, CT Basson - The lancet oncology, 2005 - thelancet.com
… Clinical genetic analyses have shown that Carney complex is … Molecular genetic studies
show that mutations in the … A, are the cause of Carney complex in most patients. Investigation of …

Gene-to-phenotype models and complex trait genetics

M Cooper, DW Podlich, OS Smith - Australian Journal of …, 2005 - CSIRO Publishing
… To be able to move from the level of studying G→P models to complex trait genetics and
predict outcomes from breeding, we need to better understand the molecular genetic basis of …

Supergenes and complex phenotypes

T Schwander, R Libbrecht, L Keller - Current Biology, 2014 - cell.com
… a panoply of complex phenotypes, including locally adapted … the spread of complex phenotypes
across species boundaries. … genetic architectures for convergently evolved phenotypes. …

The broad autism phenotype: a complementary strategy for molecular genetic studies of autism

J Piven - American journal of medical genetics, 2001 - Wiley Online Library
… more broadly defined autism phenotype in nonautistic relatives of autistic individuals provide
one potential complementary strategy for finding genes underlying this complex phenotype. …

The molecular genetics of Joubert syndrome and related ciliopathies: The challenges of genetic and phenotypic heterogeneity

MA Parisi - Translational science of rare diseases, 2019 - content.iospress.com
molecular genetics of JS, while also including genetics-based discussion of other relevant
ciliary disorders with overlapping phenotypes… MKS complex are encoded by genes implicated …

Genetics and drug use as a complex phenotype

CN Lessov, GE Swan, HZ Ring, TV Khroyan… - Substance use & …, 2004 - Taylor & Francis
Molecular Genetic Studies of Smoking Behavior In the past two decades, the advance in
molecular genetics has revolutionized our understanding of inherited disorders and behaviors. …

Phenotypic integration: studying the ecology and evolution of complex phenotypes

M Pigliucci - Ecology letters, 2003 - Wiley Online Library
… I suggest that studying integration provides a particularly stimulating and truly
interdisciplinary convergence of researchers from fields as disparate as molecular genetics, …

Systems genetics approaches to understand complex traits

M Civelek, AJ Lusis - Nature Reviews Genetics, 2014 - nature.com
genetics studies in the past decade have addressed some classic questions about the
underlying molecular genetic architecture of complex … flow from DNA to phenotype? And what is …