Onco-proteogenomics: Multi-omics level data integration for accurate phenotype prediction

L Dimitrakopoulos, I Prassas… - Critical Reviews in …, 2017 - Taylor & Francis
… , but the observed phenotype is … phenotype, because the powerful analytical tool of mass
spectrometry has reached a point of maturity to serve this purpose effectively. This integration of …

Data integration methods for phenotype harmonization in multi-cohort genome-wide association studies with behavioral outcomes

JM Luningham, DB McArtor, AM Hendriks… - Frontiers in …, 2019 - frontiersin.org
… , psychological, or other complex phenotypes have been measured by different means
across the studies. The most practical and widely used phenotype scoring approach is forming a …

Integrating clinical and laboratory data in genetic studies of complex phenotypes: A network‐based data management system

FJ McMahon, CJM Thomas, RJ Koskela… - American journal of …, 1998 - Wiley Online Library
… The integration of such large volumes of clinical and laboratory data has become a major …
in genetic studies of complex phenotypes. Gene identification in complex phenotypes may re…

Discovery of rare variants for complex phenotypes

JA Kosmicki, CL Churchhouse, MA Rivas, BM Neale - Human genetics, 2016 - Springer
… With the falling cost of WGS, rare variants are now being included in large association
studies, allowing researchers to ask what role they play in complex phenotypes. While WGS is a …

Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells

R Cavill, A Kamburov, JK Ellis… - PLoS computational …, 2011 - journals.plos.org
phenotyping could play a role in predicting response to platinum chemotherapy and that
consensus-phenotype integration of … for exploring the complex relationships between biological …

Epigenomics as a paradigm to understand the nuances of phenotypes

C Fanter, C Madelaire, DP Genereux… - Journal of …, 2022 - journals.biologists.com
… In doing so, we highlight how deeper exploration of complex phenotypes can … Integration
will be especially important across disciplines, as we move forward in understanding complex

Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies

J Bousquet, C Jorgensen, M Dauzat… - Current …, 2014 - ingentaconnect.com
… This requires an integrated systems medicine approach that leverages from (i) extensively
characterized patients, (ii) the integration of clinical and biological data into NCD phenotypes

Phenotypic plasticity in development and evolution: facts and concepts

G Fusco, A Minelli - … Transactions of the Royal Society B …, 2010 - royalsocietypublishing.org
… exploring the potential of an integrated developmental and environmental approach to
explaining the evolution of metazoan life cycles, with special focus on complex life cycles and the …

Metabolomic approaches to phenotype characterization and applications to complex diseases

M Orešič, A Vidal-Puig, V Hänninen - Expert review of molecular …, 2006 - Taylor & Francis
… of complex phenotypes as well as for the development of biomarkers for specific
physiological responses. Therefore, metabolomics is a valuable platform for studies of complex

Reprint of “Abstraction for data integration: Fusing mammalian molecular, cellular and phenotype big datasets for better knowledge extraction”

AD Rouillard, Z Wang, A Ma'ayan - Computational biology and chemistry, 2015 - Elsevier
… Second, OMIM is focused on phenotypes that obey Mendelian rules of inheritance, whereas
GWAS often identify QTL for complex phenotypes, such as obesity, which are partially …