… by the orientation of its mitotic spindle at metaphase. Spindle orientation is therefore important
… In multiple cell types in multiple animals, spindle orientation is controlled by a conserved …

… of the LGN complex with only one spindle pole oriented at the … With the LGN complex
positioned, NuMA acts as the bridge … , the spindle pole is positioned adjacent to the LGN complex, …

… embryo and rotation of the centrosome–pronuclear complex so that the metaphase spindle
forms in the center of the embryo with its poles oriented along the anterior-posterior axis of …

… Cell junctional complexes appear to provide an additional cortical cue for spindle orientation
that is independent of Pins–NuMA [44, 45]. For example, downregulation of LGN (human …

… spindle orientation impacts tissue architecture in epithelia and its emerging links to the
regulation of cell fate decisions. Finally, we describe how defective spindle orientation … complex …

… modelling show that both spindle orientation and positioning are driven by the attachment
of astral microtubule plus-ends to cortically-anchored dynein–dynactin complex, resulting in …

… of spindle orientation. Here, we highlight the dynamic nature of the assembly of this complex
… Altogether, spindle orientation and positioning are involved in fundamental developmental …

… of these complexes act independently versus coordinately in governing spindle orientation …
the cells themselves, dependent upon neither spindle orientation nor cellular positioning [75]. …

… linker domain of Pins is required for spindle positioning. (b) … on spindle orientation through
the dynein/dynactin complex; this complex is required for spindle rocking and orientation in …

… list of spindle orientation regulators, and a molecular model for how cells couple cortical polarity
with spindle positioning … that the PAR complex also regulates spindle orientation and the …