… ) values of twenty-one compounds against EGFR wt were less than 50 nM, and those of six
… EGFR mutations L858R and delE746_A750, which account for 90% of all EGFR mutations in …

… Besides, Ding group found that compound 12 potently inhibited EGFR C797S mutated …
as HBA in this study, and compound D9 was a potent promising EGFR L858 R/T790 M/C797S …

… or mutation Epidermal growth factor receptor (EGFR). The … of EGFR mutations are either
EGFR exon 19 deletion mutation (… compounds could selectively induce degradation of EGFR …

… (indicated at top) were treated with either DMSO or EGFR … expressing single or compound
EGFR mutations (indicated at … TKI sensitivity of EGFR compound mutants using the MANO …

… combined with other mutations. To the … EGFR L858R + A871G compound mutation achieving
a 5-year progression-free survival (PFS) following postoperative treatment with the EGFR-…

… the structure of the wild-type EGFR kinase and the L858R and G719S mutants in complex
with inhibitors including gefitinib, AEE788, the staurosporine compound AFN941, and the ATP …

… inhibitory of the compounds against cancer cell lines with low level of EGFR expression was
… The cancer cell lines A549 express low levels of EGFR (WT EGFR and k-Ras mutation) and …

… To appraise the potency for EGFR inhibitory activity, synthesized compounds 5(ap) were
tested against HCC827 cell line, harboring an EGFR-activating mutation (EGFR Del E746-A750…

… of non-small cell lung cancer patients with mutated EGFR and marginal in EGFR tumors [22]. …
idea of designing compounds with interactions at the active binding site of EGFR that could …

… a novel compound 11eg as a potent EGFR C797S inhibitor. … To verify whether the selected
compounds exhibiting better … different EGFR mutants, including PC-9 expressing EGFR L858R…