… Three isozymes of proline hydroxylase were designated as prolyl hydroxylase domain (PHD)1-3
[15] and an asparagine residue hydroxylase as a factor inhibiting HIF (FIH)-1 [16,17]. …

… Objective: The objective of this study is to provide a comprehensive review of chemistry, …
Corporation in May 2007 on the preparation of various prolyl hydroxylase inhibitors disclosed …

… The aim of this systematic review and meta-analysis is to assess the efficacy and safety
of hypoxia-induced factor prolyl hydroxylase inhibitor in patients with chronic kidney disease. …

… A prolyl hydroxylase domain protein acts on the hypoxia … Here, we review the enzymic
catalysts of prolyl hydroxylation, … Prolyl hydroxylation inhibits the enzymatic activity of IKKβ, which …

… PHD enzyme inhibitors, some of which are currently being tested in humans. In this Review,
we summarize current understanding of the therapeutic use of PHD enzyme inhibitors. In …

… Because they are not bioengineered, 2OG inhibitors of HIF prolyl hydroxylase may be
less expensive to produce than erythropoietin analogs. Furthermore, they are bioavailable, …

… inhibitors were considered useful in the treatment of neurological disorders. A comprehensive
review has compiled the assay procedures used to screen PHD inhibitors. (55) A separate …

… hydroxylase domain (PHD) dioxygenases. Shown on the right are the chemical structures of
HIF-prolyl hydroxylase inhibitors (… ligase complex and requires prolyl hydroxylation. PHD1, …

… this review, we have discussed the efficacy and effect of small molecules that act as prolyl
hydroxylase domain inhibitors (… The authors hope to present a complete review of most of the …

… , had been investigating collagen prolyl hydroxylase inhibitors as antifibrotic agents when …
a number of PHD-inhibitors that are now undergoing clinical trials. Peer-reviewed data are not …