Computational analysis of a 3D mucociliary clearance model predicting nasal drug uptake
… suspension, where solid drug particles are dispersed within a … drug particles in the nasal
cavity. This 3D MCC model was employed to analyze the fate of these undissolved particles …
cavity. This 3D MCC model was employed to analyze the fate of these undissolved particles …
Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics
A Ziemys, S Klemm, M Milosevic, K Yokoi, M Ferrari… - Drug …, 2016 - Taylor & Francis
… of the molecules or particles. Also, the model includes motion of particles within fluid which
is … For simplicity, we neglect drug vector (particle) degradation and consider that drug vector …
is … For simplicity, we neglect drug vector (particle) degradation and consider that drug vector …
Computational analyses of a pressurized metered dose inhaler and a new drug–aerosol targeting methodology
C Kleinstreuer, H Shi, Z Zhang - Journal of aerosol medicine, 2007 - liebertpub.com
… as new targeted drug–aerosol delivery for various lung and other diseases make detailed
… analyses imperative. For the first time, experimentally validated computational fluid-particle …
… analyses imperative. For the first time, experimentally validated computational fluid-particle …
Computational modeling of nanoparticle targeted drug delivery
… This article discusses a few computational tools to model the nanoparticle delivery process
… drug particles and receptors, expressed at the disease cell membrane, drug loaded particles …
… drug particles and receptors, expressed at the disease cell membrane, drug loaded particles …
A computational analysis on the impact of multilevel laryngotracheal stenosis on airflow and drug particle dynamics in the upper airway
… drug delivery, how effective are they in delivering drugs to the stenotic region of the patients
with LTS? In a prior work by our group involving computational … pattern of particle deposition …
with LTS? In a prior work by our group involving computational … pattern of particle deposition …
Magnetic drug targeting through a realistic model of human tracheobronchial airways using computational fluid and particle dynamics
… Using magnetic drug particles under the influence of an external magnetic field, the drug
particles are navigated toward the target region. Herein, computational fluid dynamics was …
particles are navigated toward the target region. Herein, computational fluid dynamics was …
Computational pharmaceutics-A new paradigm of drug delivery
W Wang, Z Ye, H Gao, D Ouyang - Journal of Controlled Release, 2021 - Elsevier
… analyze complex systems. Thus, a data-intensive research pattern, which applies computational
analysis … For drug particles in special shapes like spheres, thin-film, and cylinders, there …
analysis … For drug particles in special shapes like spheres, thin-film, and cylinders, there …
Computational analysis of aerosol-dynamics in a human whole-lung airway model
AV Kolanjiyil, C Kleinstreuer - Journal of Aerosol Science, 2017 - Elsevier
… Computational Fluid-Particle Dynamics (CF-PD), a modeling approach in which the
laminar/turbulent airflow and particle … of the size-range of pulmonary drugs or air-pollutants. The …
laminar/turbulent airflow and particle … of the size-range of pulmonary drugs or air-pollutants. The …
Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part II: Dry powder inhaler application
AV Kolanjiyil, C Kleinstreuer, RT Sadikot - Computers in biology and …, 2017 - Elsevier
… drug particles via the shear forces generated by the inhaled airflow [8], [12]. Hence, the amount
of drug … vivo measurement methods, computational analysis has significant advantages …
of drug … vivo measurement methods, computational analysis has significant advantages …
Computational evaluation of drug delivery in human respiratory tract under realistic inhalation
… respiratory tract (HRT) for different drug particle sizes is computed using the discrete … analysis
is carried out in a human respiratory system up to the sixth-generation bronchi. The particle …
is carried out in a human respiratory system up to the sixth-generation bronchi. The particle …
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