… or concentration of a given ligand and its effect is a characteristic and important descriptor of
many biological systems varying in complexity from isolated enzymes … inhibitors of enzymes. …

… inhibitor only binds to the enzyme at very low concentrations of substrate (ie, an effect on V
… However, at infinitely high levels of substrate the inhibitor does not bind (ie, no effect on V …

… as a function of both changing substrate and changing inhibitor concentrations. Here too,
I suggest we take an approach that is a departure from tradition but will lead to a much firmer …

… the potential role of ACE inhibition in affecting EPO concentrations in healthy volunteers. …
not the changes in EPO concentrations were due to an individual agent or to a class effect. …

… If it were to occur in vivc therapeutic concentrations of ACE-inhil this effect could be particularly
important level of the resistance vessels, since the arte possess a high degree of inherent …

… inhibitory effect on ANG l-converting enzyme in … enzyme 'concentration' was obtained
both in stored and in freshly prepared plasma samples. Measurements of converting enzyme '…

… enzyme inhibition will necessarily involve a study of the kinetics of the enzyme in the absence
of inhibitor… can be determined by measuring the effect of inhibitor concentration on the rate …

… concentration of 2.0 mg per deciliter (177 μmol per liter), 55 percent in the subgroup with
a concentration of … 17 percent in the subgroup with a concentration of 1.0 mg per deciliter (88.4 …

… , respectively) and Y-int (ac, bc, cc and dc for competitive, noncompetitive, uncompetitive
and mixed inhibitors, respectively) on the inhibitor concentration can also be used to evaluate …

… It is not necessarily the inhibitor with the lowest K,-value that is most favourable in vivo, …
concentration will determine the lower limit of the required plasma concentration of the inhibitor. …