… BRAF V600E mutant glioma cell lines, which point to re-activation of MAPK pathway and
increased AKT and EGFR signaling activity as a mechanisms of adaptation and resistance to …

… Simultaneous targeting of both MEK and ERK nodes results … of dual node suppression
of MEK and ERK based upon the … of MAPK signaling that would delay pathway reactivation …

… Reactivation of the MAPK pathway occurred primarily via alterations … simultaneous inhibition
of BRAF and MEK1/2 may negate many MAPK resistance effectors signalling above MEK…

… consistent with reactivation of RAF/MEK/ERK signaling (17, 18). … the requirement for reactivation
of RAF/MEK/ERK signaling. … approaches that look at simultaneous or sequential use of …

… mRNA expression concurrent with … of MEK/ERK reactivation but might be intercepted
through combined therapeutic modalities for MAPK pathway inhibition (for example, RAF/MEK or …

… upstream regulators of the MAPK pathway is frequent in the … that concurrent administration
of BRAF and MEK inhibitors is … MEK2 escaped inhibition, allowing reactivation of ERK. Thus, …

… (MAPK) kinase (MEK)… MEK inhibitor may delay or overcome drug resistance. The data thus
provide a mechanistic basis for ongoing trials testing concurrent treatment with RAF and MEK …

… Paradoxically, D/T treatment induces upregulation of pMEK1/2 (with concurrent downregulation
of total MEK) despite the presence of trametinib (MEKi). This phenomenon has been …

… These include reactivation of the MAPK pathway resulting in continued extracellular signal-…
Furthermore, targeting both the MAPK and PI3K/mTOR pathways concurrently may also help …

… dual therapeutic effects with simultaneous suppression of PD-… counteract BRAFi resistance
of MAPK reactivation and also for … In the present study, we found that the reactivation of MAPK …