[HTML][HTML] Emerging functions and clinical prospects of connexins and pannexins in melanoma

A Varela-Vázquez, A Guitián-Caamaño… - … et Biophysica Acta (BBA …, 2020 - Elsevier
… by connexins and through channels made by pannexins … target connexins and pannexins
are providing novel clinical … the role of connexins and pannexins in malignant melanoma. …

Next-generation connexin and pannexin cell biology

JL Esseltine, DW Laird - Trends in cell biology, 2016 - cell.com
… Advancements in connexin and pannexin biology in recent … evidence suggests that connexins
and pannexins participate in … classical functions of connexins and pannexins but focus our …

Connexins and pannexins: from biology towards clinical targets

P Meda, JA Haefliger - Swiss medical weekly, 2016 - smw.ch
… Here, we review the biological essentials of the connexin and pannexin families, and the …
how connexins and pannexins participate in human pathology, and the clinical perspectives …

Connexin therapeutics: Blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions

ML Acosta, MNM Nor, CX Guo… - Neural regeneration …, 2021 - journals.lww.com
… this review describes current knowledge of connexin and pannexin protein channels, their
… We summarize the evidence implicating pannexins and connexins in disease, considering …

Connexin and pannexin mediated cell–cell communication

E Scemes, SO Suadicani, G Dahl, DC Spray - Neuron glia biology, 2007 - cambridge.org
… (connexins) and protostomes (innexins), and that channels formed of the deuterostome
homologues of innexins (pannexins) differ from connexin … , both connexins and pannexins are …

Pannexin biology and emerging linkages to cancer

DW Laird, S Penuela - Trends in cancer, 2021 - cell.com
Pannexins are a family of glycoproteins that comprises three … metastasis, suggesting that
pannexin-blocking therapeutics … the past 5 years that suggest pannexins facilitate, or in some …

Mind the gap: connexins and pannexins in platelet function

KA Taylor, G Little, JM Gibbins - Platelets, 2021 - Taylor & Francis
… Platelets express pannexin-1 and several connexin family members (… and function of platelet
pannexin-1 and connexins, the … -related diseases and their prospects as antiplatelet targets. …

Mechanisms of connexin regulating peptides

DR King, MW Sedovy, X Leng, J Xue… - International Journal of …, 2021 - mdpi.com
… inhibit pannexinpannexin channels similarly to the connexin-mimetic peptides. This along
with the inhibitory activity of scrambled 32 Gap24 peptides suggests inhibition of pannexins

Connexins: A Brief Overview

JS Fang, JF Ek-Vitorin - Bioelectricity, 2023 - liebertpub.com
… Since 1974, a conference focused on connexin channel … of pannexins—proteins with structural
similarities to connexins but … the prospect that connexons from other connexins may also …

Gap junctions, pannexins and pain

DC Spray, M Hanani - Neuroscience letters, 2019 - Elsevier
Enhanced expression and function of gap junctions and pannexin (Panx) channels have been
associated with both peripheral and central mechanisms of pain sensitization. At the level …