Integrative genome modeling platform reveals essentiality of rare contact events in 3D genome organizations
… frequency interchromosomal contacts are essential to correctly predict whole-genome structure
organizations: … interchromosomal contacts severely fails at reproducing the correct global …
organizations: … interchromosomal contacts severely fails at reproducing the correct global …
Computational methods for analysing multiscale 3D genome organization
… loops are pairs of genomic loci that have higher contact frequency than expected based on
… type or species as well as in time-course events such as differentiation. To address this issue, …
… type or species as well as in time-course events such as differentiation. To address this issue, …
Organizational principles of 3D genome architecture
… Features of chromatin organization Contact maps of Hi-C data showed a genome-wide
view of … Regular extrusion events causing gene activation at discrete times may explain …
view of … Regular extrusion events causing gene activation at discrete times may explain …
Insights about genome function from spatial organization of the genome
SS Roy, AK Mukherjee, S Chowdhury - Human genomics, 2018 - Springer
… contact reads were used to construct genome-wide contact … model to define chromatin
organization since they are free of … , for instance, during gene regulatory events like activation and …
organization since they are free of … , for instance, during gene regulatory events like activation and …
Population-based 3D genome structure analysis reveals driving forces in spatial genome organization
… of 3D genome structures whose macrodomain contacts … relevance in chromosome translocation
events occurring in Burkitt’s … description of the entire genome organization. The level of …
events occurring in Burkitt’s … description of the entire genome organization. The level of …
The stochastic nature of genome organization and function
… that an enhancer must physically contact a target promoter. … to the target promoter around
bursting events [59], whereas … event leaves a ‘tag’ that contributes towards activation of a …
bursting events [59], whereas … event leaves a ‘tag’ that contributes towards activation of a …
Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data
… levels of chromosome organization (including looping events, … Contact probability and
genomic distance: the fractal globule… decrease of the contact probability P with genomic distance s…
genomic distance: the fractal globule… decrease of the contact probability P with genomic distance s…
[HTML][HTML] 3D genome organization: causes and consequences for DNA damage and repair
À Carré-Simon, E Fabre - Genes, 2022 - mdpi.com
… TADs are characterized by more enriched contacts in close proximity than with other parts
of … By time-lapse imaging, it is found that FET proteins undergo fusion and fission events, as …
of … By time-lapse imaging, it is found that FET proteins undergo fusion and fission events, as …
3C and 3C-based techniques: the powerful tools for spatial genome organization deciphering
J Han, Z Zhang, K Wang - Molecular Cytogenetics, 2018 - Springer
… a finer and more accurate contact profiles of entire genome and ultimately reveal specific …
and sequencing, allows researchers to detect contact events within a particular locus (Fig. 1). …
and sequencing, allows researchers to detect contact events within a particular locus (Fig. 1). …
Technologies to study spatial genome organization: beyond 3C
N Übelmesser, A Papantonis - Briefings in Functional Genomics, 2019 - academic.oup.com
… The existence of TADs as architectural units of genome organization was also confirmed
in … stemming from intra-TAD conformations and cis or trans inter-TAD contact events [65]. …
in … stemming from intra-TAD conformations and cis or trans inter-TAD contact events [65]. …
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