[HTML][HTML] Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury
Q Zhang, B Yu, Y Zhang, Y Tian, S Yang… - Frontiers in …, 2023 - frontiersin.org
… Consistently, immune infiltration analysis in the current study showed that levels of M2 … and
activated NK cell), which is closely related to the destruction of the blood–spinal cord barrier. …
activated NK cell), which is closely related to the destruction of the blood–spinal cord barrier. …
Traumatic spinal cord injury induces nuclear factor-κB activation
… and play a central role in mediating the pathogenesis of acute and chronic spinal cord injury
… , and cell death responses of cells. In this study we examined the temporal and cellular …
… , and cell death responses of cells. In this study we examined the temporal and cellular …
The paradox of chronic neuroinflammation, systemic immune suppression, autoimmunity after traumatic chronic spinal cord injury
… chronic stages of recovery after spinal cord injury (SCI), there is … Since injury directly affects
cells embedded within the “immune … T-cell infiltrates plateau early with ~ 10% of maximal cell …
cells embedded within the “immune … T-cell infiltrates plateau early with ~ 10% of maximal cell …
[HTML][HTML] Evaluation of early and late effects into the acute spinal cord injury of an injectable functionalized self-assembling scaffold
D Cigognini, A Satta, B Colleoni, D Silva, M Donega… - PloS one, 2011 - journals.plos.org
… Hystological analysis revealed that 8 weeks after SCI our scaffold increased cellular
infiltration, basement membrane deposition and axon regeneration/sprouting within the cyst. …
infiltration, basement membrane deposition and axon regeneration/sprouting within the cyst. …
T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity
M Costigan, A Moss, A Latremoliere… - Journal of …, 2009 - Soc Neuroscience
… the adult but not the neonatal dorsal horn following injury To determine the extent and
distribution of T-cell infiltration in the spinal cord after adult or P10 SNI surgery, we used CD2 …
distribution of T-cell infiltration in the spinal cord after adult or P10 SNI surgery, we used CD2 …
Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury
Y Pomeshchik, I Kidin, P Korhonen… - Brain, behavior, and …, 2015 - Elsevier
… To estimate the effect of IL-33 treatment on T cell infiltration into the injured spinal cord we …
markers for total T cell population and T-helper cells, respectively, in the spinal cord at 8 dpi. In …
markers for total T cell population and T-helper cells, respectively, in the spinal cord at 8 dpi. In …
Molecular targets in spinal cord injury
S Klussmann, A Martin-Villalba - Journal of molecular medicine, 2005 - Springer
… This leads to a deleterious inflammatory response that enhances cell death. Neutrophils,
macrophages and T-cells start infiltrating the injured spinal cord within hours after injury. …
macrophages and T-cells start infiltrating the injured spinal cord within hours after injury. …
[HTML][HTML] Depletion of microglia exacerbates injury and impairs function recovery after spinal cord injury in mice
H Fu, Y Zhao, D Hu, S Wang, T Yu, L Zhang - Cell death & disease, 2020 - nature.com
… The role of microglia in spinal cord injury (SCI) remains … and did not affect other cell types in
mouse spinal cord. PLX3397 … formation, enhanced immune cell infiltrates, reduced neuronal …
mouse spinal cord. PLX3397 … formation, enhanced immune cell infiltrates, reduced neuronal …
Neuroinflammation in spinal cord injury: therapeutic targets for neuroprotection and regeneration
JK Alexander, PG Popovich - Progress in brain research, 2009 - Elsevier
… Traumatic spinal cord injury triggers a complex local … The composition and effector potential
of the post-injury cellular and … also infiltrate the injured mammalian spinal cord, albeit in …
of the post-injury cellular and … also infiltrate the injured mammalian spinal cord, albeit in …
Estrogen attenuated markers of inflammation and decreased lesion volume in acute spinal cord injury in rats
EA Sribnick, JM Wingrave, DD Matzelle… - Journal of …, 2005 - Wiley Online Library
… Infiltration of Inflammatory Cells To assess the degree of inflammatory cell infiltration, 5-μm
slices of spinal cord from the lesion and caudal penumbra were examined by …
slices of spinal cord from the lesion and caudal penumbra were examined by …