[HTML][HTML] Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury

Q Zhang, B Yu, Y Zhang, Y Tian, S Yang… - Frontiers in …, 2023 - frontiersin.org
… Consistently, immune infiltration analysis in the current study showed that levels of M2 … and
activated NK cell), which is closely related to the destruction of the blood–spinal cord barrier. …

Traumatic spinal cord injury induces nuclear factor-κB activation

JR Bethea, M Castro, RW Keane, TT Lee… - Journal of …, 1998 - Soc Neuroscience
… and play a central role in mediating the pathogenesis of acute and chronic spinal cord injury
… , and cell death responses of cells. In this study we examined the temporal and cellular

The paradox of chronic neuroinflammation, systemic immune suppression, autoimmunity after traumatic chronic spinal cord injury

JM Schwab, Y Zhang, MA Kopp, B Brommer… - Experimental …, 2014 - Elsevier
… chronic stages of recovery after spinal cord injury (SCI), there is … Since injury directly affects
cells embedded within the “immune … T-cell infiltrates plateau early with ~ 10% of maximal cell

[HTML][HTML] Evaluation of early and late effects into the acute spinal cord injury of an injectable functionalized self-assembling scaffold

D Cigognini, A Satta, B Colleoni, D Silva, M Donega… - PloS one, 2011 - journals.plos.org
… Hystological analysis revealed that 8 weeks after SCI our scaffold increased cellular
infiltration, basement membrane deposition and axon regeneration/sprouting within the cyst. …

T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity

M Costigan, A Moss, A Latremoliere… - Journal of …, 2009 - Soc Neuroscience
… the adult but not the neonatal dorsal horn following injury To determine the extent and
distribution of T-cell infiltration in the spinal cord after adult or P10 SNI surgery, we used CD2 …

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

Y Pomeshchik, I Kidin, P Korhonen… - Brain, behavior, and …, 2015 - Elsevier
… To estimate the effect of IL-33 treatment on T cell infiltration into the injured spinal cord we …
markers for total T cell population and T-helper cells, respectively, in the spinal cord at 8 dpi. In …

Molecular targets in spinal cord injury

S Klussmann, A Martin-Villalba - Journal of molecular medicine, 2005 - Springer
… This leads to a deleterious inflammatory response that enhances cell death. Neutrophils,
macrophages and T-cells start infiltrating the injured spinal cord within hours after injury. …

[HTML][HTML] Depletion of microglia exacerbates injury and impairs function recovery after spinal cord injury in mice

H Fu, Y Zhao, D Hu, S Wang, T Yu, L Zhang - Cell death & disease, 2020 - nature.com
… The role of microglia in spinal cord injury (SCI) remains … and did not affect other cell types in
mouse spinal cord. PLX3397 … formation, enhanced immune cell infiltrates, reduced neuronal …

Neuroinflammation in spinal cord injury: therapeutic targets for neuroprotection and regeneration

JK Alexander, PG Popovich - Progress in brain research, 2009 - Elsevier
… Traumatic spinal cord injury triggers a complex local … The composition and effector potential
of the post-injury cellular and … also infiltrate the injured mammalian spinal cord, albeit in …

Estrogen attenuated markers of inflammation and decreased lesion volume in acute spinal cord injury in rats

EA Sribnick, JM Wingrave, DD Matzelle… - Journal of …, 2005 - Wiley Online Library
Infiltration of Inflammatory Cells To assess the degree of inflammatory cell infiltration, 5-μm
slices of spinal cord from the lesion and caudal penumbra were examined by …