The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities
X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
… pathway, we summarized the mechanisms of secondary TSCI and the PI3K/AKT signaling
pathway; we … future treatment methods for TSCI based on the PI3K/AKT signaling pathway. …
pathway; we … future treatment methods for TSCI based on the PI3K/AKT signaling pathway. …
[HTML][HTML] Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms
A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing … changes that occur in the injured spinal
cord. Therefore, in the past few … mechanisms of tissue degeneration and repair in the injured …
cord. Therefore, in the past few … mechanisms of tissue degeneration and repair in the injured …
[HTML][HTML] Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms
A Anjum, MD Yazid, M Fauzi Daud, J Idris… - International journal of …, 2020 - mdpi.com
… Spinal cord injury (SCI) is a destructive neurological and … , inflammatory events, apoptotic
pathways and locomotor dysfunctions. … Apoptotic Pathways: The apoptotic pathways are further …
pathways and locomotor dysfunctions. … Apoptotic Pathways: The apoptotic pathways are further …
[HTML][HTML] The regenerative effect of trans-spinal magnetic stimulation after spinal cord injury: Mechanisms and pathways underlying the effect
Spinal cord injury (SCI) leads to a loss of sensitive and motor functions. Currently, there is
no therapeutic intervention offering a complete recovery. Here, we report that repetitive trans-…
no therapeutic intervention offering a complete recovery. Here, we report that repetitive trans-…
Recovery of function after spinal cord injury: mechanisms underlying transplant-mediated recovery of function differ after spinal cord injury in newborn and adult rats
BS Bregman, E Kunkel-Bagden, PJ Reier, HN Dai… - Experimental …, 1993 - Elsevier
… pathways are which are capable of robust transplant-induced growth after spinal cord injury
at … pattern of restriction with increasing age at time of injury. We suggest that the restriction in …
at … pattern of restriction with increasing age at time of injury. We suggest that the restriction in …
[HTML][HTML] Neuroprotection and its molecular mechanism following spinal cord injury☆
NK Liu, XM Xu - Neural regeneration research, 2012 - journals.lww.com
… These findings support the argument that the TNFR-NF-κB pathway is beneficial for limiting
apoptotic cell death after spinal cord injury and that a defective TNFR-NF-κB pathway results …
apoptotic cell death after spinal cord injury and that a defective TNFR-NF-κB pathway results …
Acute spinal cord injury, part I: pathophysiologic mechanisms
RJ Dumont, DO Okonkwo, S Verma… - Clinical …, 2001 - journals.lww.com
… Spinal cord injury may be divided into both primary and secondary mechanisms of injury. …
mechanisms of injury that are amenable to pharmacological interventions, unlike the primary …
mechanisms of injury that are amenable to pharmacological interventions, unlike the primary …
Inflammatory pathways in spinal cord injury
S David, JG Zarruk, N Ghasemlou - International review of neurobiology, 2012 - Elsevier
… As inflammation in SCI is a complex process involving a number of cellular and molecular
pathways, we used different strategies to identify novel molecular targets. (i) One approach …
pathways, we used different strategies to identify novel molecular targets. (i) One approach …
Degenerative and regenerative mechanisms governing spinal cord injury
C Profyris, SS Cheema, DW Zang, MF Azari… - Neurobiology of …, 2004 - Elsevier
Spinal cord injury (SCI) is a major cause of disability, and at present, … injury and secondary
pathophysiological mechanisms that are induced by the initial trauma. These mechanisms …
pathophysiological mechanisms that are induced by the initial trauma. These mechanisms …
Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade
C Oyinbo - Acta neurobiologiae experimentalis, 2011 - ane.pl
… comprehensive catalog of these mechanisms are not readily … mechanisms of injury in the
spinal cord in an open access portal, and is particularly versatile for starters in spinal cord injury …
spinal cord in an open access portal, and is particularly versatile for starters in spinal cord injury …
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