[HTML][HTML] Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury

RB Shultz, Y Zhong - Neural regeneration research, 2017 - journals.lww.com
… The secondary injury mechanisms that … injury mechanisms, MH treatment holds great
promise for reducing tissue damage and promoting functional recovery following spinal cord injury

Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice

JEA Wells, RJ Hurlbert, MG Fehlings, VW Yong - Brain, 2003 - academic.oup.com
… that minocycline treatment significantly attenuated mortality (Fig. 1). Over a 3 week post‐injury
Pharmacological treatment of acute spinal cord injury: how do we build on past success? …

Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury

S Casha, D Zygun, MD McGowan, I Bains, VW Yong… - Brain, 2012 - academic.oup.com
… The minocycline regimen established in this study proved feasible, safe and was associated
… Although this study does not establish the efficacy of minocycline in spinal cord injury the …

Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury

BW Festoff, S Ameenuddin, PM Arnold… - Journal of …, 2006 - Wiley Online Library
… or minocycline treatment by qRT–PCR performed with RNAs extracted from injured tetracycline-
and minocycline-treated spinal cords … expression was altered at 24 h after injury (Fig. 6). …

Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury

DP Stirling, K Khodarahmi, J Liu… - Journal of …, 2004 - Soc Neuroscience
cord injury (SCI). However, the cellular consequences of minocycline treatment on the
secondary injury … We examined the ability of minocycline to reduce oligodendrocyte apoptosis, …

Minocycline reduces the severity of autonomic dysreflexia after experimental spinal cord injury

JW Squair, I Ruiz, AA Phillips, MMZ Zheng… - Journal of …, 2018 - liebertpub.com
… whether minocycline treatment resulted in better blood pressure control. Of the 18 minocycline
… of experiments, four minocycline treated rats and four vehicle treated rats were excluded …

Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury

YD Teng, H Choi, RC Onario, S Zhu… - Proceedings of the …, 2004 - National Acad Sciences
… To evaluate whether systemic minocycline treatment reduced lesion volume, we outlined
the lesion area in transverse sections of the cord sampled from the injury epicenter and …

Effects of Etanercept and Minocycline in a rat model of spinal cord injury

F Marchand, C Tsantoulas, D Singh, J Grist… - European Journal of …, 2009 - Elsevier
… immediate minocycline treatment reduced thermal stimulus-induced c-Fos expression via
a decrease of microglial OX-42 expression suggesting a direct inhibitory effect of minocycline

Minocycline treatment inhibits lipid peroxidation, preserves spinal cord ultrastructure, and improves functional outcome after traumatic spinal cord injury in the rat

E Sonmez, S Kabatas, O Ozen, G Karabay, S Turkoglu… - Spine, 2013 - journals.lww.com
… evaluate the efficacy of minocycline treatment on lipid peroxidation. … SCI, we initiate the
minocycline treatment just after the trauma … stress parameters, minocycline treatment inhibits lipid …

Therapeutic effects of minocycline pretreatment in the locomotor and sensory complications of spinal cord injury in an animal model

K Afshary, M Chamanara, B Talari, P Rezaei… - Journal of Molecular …, 2020 - Springer
minocycline prophylactic treatment was evaluated and compared to its post-injury treatment
in a rat model of spinal cord … Interestingly, our results showed that minocycline pretreatment …