[HTML][HTML] Bone marrow mesenchymal stem cells combined with minocycline improve spinal cord injury in a rat model

D Chen, W Zeng, Y Fu, M Gao, G Lv - International Journal of …, 2015 - ncbi.nlm.nih.gov
… The aims of this study were to assess that the effects of bone marrow mesenchymal stem
cells (BMSCs) combination with minocycline improve spinal cord injury (SCI) in rat model. In …

Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat

SM Lee, TY Yune, SJ Kim, DW Park, YK Lee… - Journal of …, 2003 - liebertpub.com
… We examined the effects of minocycline, an anti-inflammatory drug, on functional … cord injury
(SCI). Rats received a mild, weight-drop contusion injury to the spinal cord and were treated

Limited minocycline neuroprotection after balloon-compression spinal cord injury in the rat

K Saganová, J Orendáčová, D Čížková, I Vanický - Neuroscience letters, 2008 - Elsevier
… reportedly provides neuroprotection following CNS injury. The objective of … treatment using
balloon-compression spinal cord injury (SCI) in the rat. Rats subjected to SCI were treated

Minocycline: far beyond an antibiotic

N Garrido‐Mesa, A Zarzuelo… - British journal of …, 2013 - Wiley Online Library
cord injury. Moreover, other pre-clinical studies have shown its ability to inhibit malignant
cell growth and activation and replication of human immunodeficiency virus, and to prevent …

[HTML][HTML] … of combined treatment with minocycline and olfactory ensheathing cells transplantation against inflammation and oxidative stress after spinal cord injury

S Pourkhodadad, S Oryan, G Kaka… - Cell Journal …, 2019 - ncbi.nlm.nih.gov
… to promote locomotor function after spinal cord injury. In this study, we have tested the
efficacy of combined treatment with minocycline and OECs after contusive spinal cord injury. …

Hyperphosphorylated neurofilament NF-H as a biomarker of the efficacy of minocycline therapy for spinal cord injury

T Ueno, Y Ohori, J Ito, S Hoshikawa, S Yamamoto… - Spinal Cord, 2011 - nature.com
… We found that minocycline treatment reduced plasma pNF-H levels at 3 dpi, and this reduction
was correlated with the functional motor score; this finding is consistent with the reported …

Minocycline-Loaded poly (α-lipoic acid)–methylprednisolone prodrug nanoparticles for the combined anti-inflammatory treatment of spinal cord injury

F Lin, Y Liu, W Luo, S Liu, Y Wang, R Gu… - International Journal …, 2022 - Taylor & Francis
cord injury (TSCI) induces a powerful inflammatory response that can significantly exacerbate
the extent and severity of neural damage (termed as “secondary injury”). … at the injury site. …

Nano-carrier mediated co-delivery of methyl prednisolone and minocycline for improved post-traumatic spinal cord injury conditions in rats

S Bin, N Zhou, J Pan, F Pan, XF Wu… - Drug development and …, 2017 - Taylor & Francis
… : The objective of this study is to investigate the fate of albumin coupled nanoparticulate
system over non-targeted drug carrier in the treatment of hemisectioned spinal cord injury (SCI). …

Local delivery of minocycline from metal ion-assisted self-assembled complexes promotes neuroprotection and functional recovery after spinal cord injury

Z Wang, J Nong, RB Shultz, Z Zhang, T Kim, VJ Tom… - Biomaterials, 2017 - Elsevier
… to the secondary injury cascades following traumatic spinal cord injury (SCI). However,
most current treatment strategies only target one or a few elements in the injury cascades, and …

Effectiveness of minocycline and FK506 alone and in combination on enhanced behavioral and biochemical recovery from spinal cord injury in rats

M Ahmad, A Zakaria, KM Almutairi - Pharmacology Biochemistry and …, 2016 - Elsevier
… Our results demonstrate that treatment with both minocycline and FK506 individually and
in … starting at 1-week post injury (pi). The treated groups recovered hind limb reflexes more …