Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury

JN Chen, YN Zhang, LG Tian, Y Zhang… - Neural regeneration …, 2022 - journals.lww.com
… After transcardial perfusion with 4% paraformaldehyde, spinal cord samples from 5 mm
above and below the injured lesion were carefully removed. The samples for RNA sequencing

Specific blood RNA profiles in individuals with acute spinal cord injury as compared with trauma controls

Q Chen, L Wang, H Wu, C Ye, D Xie… - Oxidative Medicine …, 2023 - Wiley Online Library
… Several studies have suggested that CNS injury would lead to a more robust systemic …
without CNS injury, with injury to the lungs and liver [7–11]. RNA sequencing (RNA-seq) has been …

Spinal cord injury induces permanent reprogramming of microglia into a disease-associated state which contributes to functional recovery

R Hakim, V Zachariadis, SR Sankavaram… - Journal of …, 2021 - Soc Neuroscience
… single-cell RNA sequencing (… injury processes is not well understood. In this study, we
investigated the response of healthy tissue to injury, in the context of traumatic spinal cord injury (…

Changes in long non-coding RNA transcriptomic profiles after ischemia-reperfusion injury in rat spinal cord

Z Zhou, B Han, H Jin, A Chen, L Zhu - PeerJ, 2020 - peerj.com
… not select spinal cord areas for RNA isolation, RNA sequencing, or RT-PCR analyses. Besides
that, the number of animals included in each group for RNA sequencing may be relatively …

Genome‐wide identification of long noncoding rnas in human intervertebral disc degeneration by RNA sequencing

B Zhao, M Lu, D Wang, H Li… - BioMed Research …, 2016 - Wiley Online Library
… degeneration (IDD) and spinal cord injury (control) using RNA sequencing (RNA-seq). A total
of … RNA-seq profiling indicated that 1,854 lncRNAs were differentially expressed (log2 fold …

Global gene expression analysis following spinal cord injury in non-human primates

S Nishimura, T Sasaki, A Shimizu, K Yoshida… - Experimental …, 2014 - Elsevier
… We found that, although the sequence of the gene expression patterns was comparable
between common marmosets and rodents, the time course of changes in gene expression was …

A comparative analysis of differentially expressed genes in rostral and caudal regions after spinal cord injury in rats

XM Cao, SL Li, YQ Cao, YH Lv, YX Wang… - Neural regeneration …, 2022 - journals.lww.com
… The RNA sequencing (RNA-Seq) data in the rostral and caudal groups at different time points
after SCI (0 hours, 0.5 hours, 3 hours, 6 hours, 12 hours, 1 day, 3 days, 7 days, 14 days, 21 …

Heterogeneity analysis of astrocytes following spinal cord injury at single‐cell resolution

J Hou, H Bi, Q Ge, H Teng, G Wan, B Yu… - The FASEB …, 2022 - Wiley Online Library
… important functions in response to spinal cord injury (SCI) in an … RNA sequencing, we
constructed the transcriptomic profile of astrocytes from uninjured spinal cord tissue and injured

RNA-Sequencing approach for exploring the therapeutic effect of umbilical cord mesenchymal stem/stromal cells on lipopolysaccharide-induced acute lung injury

E Cui, L Zhang, X Pan, Q Zhang, L Zhang… - Frontiers in …, 2022 - frontiersin.org
Frontiers | RNA-Sequencing approach for exploring the therapeutic effect of umbilical cord
mesenchymal stem/stromal cells on lipopolysaccharide-induced acute lung injury Skip to …

Microglia-organized scar-free spinal cord repair in neonatal mice

Y Li, X He, R Kawaguchi, Y Zhang, Q Wang… - Nature, 2020 - nature.com
… Spinal cord injury in mammals is thought to trigger scar formation with little regeneration of
… Using single-cell RNA sequencing and functional analyses, we find that neonatal microglia …