Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury

AP Amar, ML Levy - Neurosurgery, 1999 - journals.lww.com
… of acute spinal cord injury (SCI) support the concepts of primary and secondary injury, in
which the … events that promote progressive tissue damage and ischemia. Whereas the primary …

Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade

C Oyinbo - Acta neurobiologiae experimentalis, 2011 - ane.pl
… Though both mechanisms are involved in the neurological dysfunction in SCI most research
however has focused on understanding the pathophysiology of the secondary damage and …

Understanding secondary injury

RB Borgens, P Liu-Snyder - The Quarterly review of biology, 2012 - journals.uchicago.edu
cord injury is due to the injury sustained by neuronal processes (axons), and not usually to
the loss or damage of … depending on the vertebral level of the spinal cord injury. High cervical …

Function of microglia and macrophages in secondary damage after spinal cord injury

X Zhou, X He, Y Ren - Neural regeneration research, 2014 - journals.lww.com
… By understanding how macrophages either promote or prevent secondary damage in spinal
cord inflammation, we may be able to deduce new approaches for mitigating the currently …

Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms

CH Tator, MG Fehlings - Journal of neurosurgery, 1991 - thejns.org
… nisms of damage to the spinal cord after acute spinal cord injury: the primary mechanical …
the importance of secondary injury mechanisms in patients with acute spinal cord injury. How…

Advances in secondary spinal cord injury: role of apoptosis

J Lu, KWS Ashwell, P Waite - Spine, 2000 - journals.lww.com
cord injury depends on the extent of secondary damage … the evidence that secondary spinal
cord injury involves the … as glutamatergic excitotoxicity, free radical damage, cytokines, and …

Inflammogenesis of secondary spinal cord injury

MA Anwar, TS Al Shehabi, AH Eid - Frontiers in cellular neuroscience, 2016 - frontiersin.org
injury along with sequential secondary damages emanating from multi-cascade of patho-mechanisms.
These secondary pathologic series of events lead to further damages to the SC. …

Acute spinal cord injury, part I: pathophysiologic mechanisms

RJ Dumont, DO Okonkwo, S Verma… - Clinical …, 2001 - journals.lww.com
… Spinal cord injury (SCI) is a devastating and common … cord injury may be divided into both
primary and secondary … However, secondary mechanisms of injury can exacerbate damage

Update on the pathophysiology and pathology of acute spinal cord injury

CH Tator - Brain pathology, 1995 - Wiley Online Library
… and experimental studies that the spinal cord suffers both primary and secondary damage
after acute spinal cord injury. The pathophysiology of secondary injury involves a multitude of …

Interactions of primary insult biomechanics and secondary cascades in spinal cord injury: implications for therapy

MB Orr, JC Gensel - Neural Regeneration Research, 2017 - journals.lww.com
… serve protective and reparative roles but also exacerbate damage and contribute to secondary
injury. The mediators of this secondary injury after SCI have been reviewed extensively (…