[HTML][HTML] Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response

Y Hou, J Luan, T Huang, T Deng, X Li, Z Xiao… - Journal of …, 2021 - Springer
… ) is a hydrophilic bile acid derivative, which has been … of TUDCA on spinal cord injury (SCI)
have not been fully elucidated. This study aims to investigate the protective effects of TUDCA

Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats

A Çolak, B Kelten, A Sağmanligil, O Akdemir… - Journal of Clinical …, 2008 - Elsevier
spinal cord injury (SCI) has led to new and innovative apoptosis-based therapies for patients
with an SCI. Tauroursodeoxycholic acid (TUDCA) is a biliary acid … efficacy of TUDCA in an …

Injectable hydrogel containing tauroursodeoxycholic acid for anti-neuroinflammatory therapy after spinal cord injury in rats

GH Han, SJ Kim, WK Ko, D Lee, JS Lee, H Nah… - Molecular …, 2020 - Springer
… containing tauroursodeoxycholic acid (TUDCA) in a spinal cord injury (SCI) model. To this
end, TUDCA-hydrogel (TC gel) is created by immersing the synthesized hydrogel in a TUDCA

… of tauroursodeoxycholic acid–inducing M2‐phenotype macrophages promotes an anti‐neuroinflammatory effect and functional recovery after spinal cord injury in rats

GH Han, SJ Kim, WK Ko, D Lee, IB Han… - Cell …, 2021 - Wiley Online Library
… Schematic procedures of the transplantation therapy of tauroursodeoxycholic acid (TUDCA)–induced
M2-phenotype macrophages in the contusion spinal cord injury (SCI) rat model in …

[HTML][HTML] Tauroursodeoxycholic acid reduces neuroinflammation but does not support long term functional recovery of rats with spinal cord injury

S Wu, C García-Rama, L Romero-Ramírez… - Biomedicines, 2022 - mdpi.com
… The bile acid tauroursodeoxycholic acid (TUDCA) … of spinal cord injury (SCI). Since cell
death of injected bmSC limits the efficacy of this treatment, the cytoprotective effect of TUDCA

[HTML][HTML] Mechanism of tauroursodeoxycholic acid-mediated neuronal protection after acute spinal cord injury through AKT signaling pathway in rats

Y Dong, S Yang, B Fu, F Liu, S Zhou… - … Journal Of Clinical …, 2020 - ncbi.nlm.nih.gov
tauroursodeoxycholic acid-(TUDCA) mediated neuronal protection after acute spinal cord
injury … group (ASCI rats), TUDCA group (ASCI rats received TUDCA treatment), MK2206 group …

[PDF][PDF] Protective effect of tauroursodeoxycholic acid on the autophagy of nerve cells in rats with acute spinal cord injury.

L Miao, Y Dong, FB Zhou, YL Chang… - European Review for …, 2018 - europeanreview.org
TUDCA administration, caspase-3 expression was lower than that of the control group, …
after TUDCA administration. Therefore, we suggest that during early spinal cord injury, TUDCA

Tauroursodeoxycholic acid alleviates secondary injury in the spinal cord via up-regulation of CIBZ gene

Z Zhang, J Chen, F Chen, D Yu, R Li, C Lv… - Cell Stress and …, 2018 - Springer
… bile acid and recognized endoplasmic reticulum (ER) stress inhibitor, tauroursodeoxycholic
acid (TUDCA) … damage by inhibiting apoptosis in the early treatment of spinal cord injury. …

[HTML][HTML] Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats

Y Dong, L Miao, L Hei, L Lin, H Ding - International journal of …, 2015 - ncbi.nlm.nih.gov
… effects of tauroursodeoxycholic acid (TUDCA) on nerve function after acute spinal cord injury
(… Methods: We used a modified Allen’s weight-drop trauma method to establish a rat acute …

Application of tauroursodeoxycholic acid for treatment of neurological and non-neurological diseases: is there a potential for treating traumatic brain injury?

KR Gronbeck, CMP Rodrigues, J Mahmoudi… - Neurocritical care, 2016 - Springer
… potential of tauroursodeoxycholic acid (TUDCA) for neuroprotection in traumatic brain injury
(… systemic effects of TUDCA, and the potential therapeutic application of TUDCA. Preclinical …