The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injury

PD Smith, F Puskas, X Meng, JH Lee, JC Cleveland Jr… - Circulation, 2012 - Am Heart Assoc
mechanisms of spinal cord ischemiamechanism to the overall effect of ischemia and
reperfusion. The present studies' characterization of the inflammatory response after spinal cord IR …

[HTML][HTML] Role of the TLR4 pathway in blood-spinal cord barrier dysfunction during the bimodal stage after ischemia/reperfusion injury in rats

XQ Li, HW Lv, WF Tan, B Fang, H Wang… - Journal of …, 2014 - Springer
… , resulting in blood-spinal cord barrier (BSCB) dysfunction … cord I/R and the events that
define its clinical progression with delayed neurological deficits, supporting a bimodal mechanism

Role of autophagy in the bimodal stage after spinal cord ischemia reperfusion injury in rats

B Fang, XQ Li, NR Bao, WF Tan, FS Chen, XL Pi… - Neuroscience, 2016 - Elsevier
… Autophagy plays an important role in spinal cord ischemia reperfusion (I/R) injury, but its …
In this study, the different roles and action mechanisms of autophagy in the early and later …

Development and Treatments of Inflammatory Cells and Cytokines in Spinal Cord Ischemia‐Reperfusion Injury

P Zhu, J Li, M Fujino, J Zhuang… - Mediators of inflammation, 2013 - Wiley Online Library
… IL-8 level was increased and peaked at 12 hours after the transient ischemia. The biphasic
expression of inflammatory cytokines would support a bimodal mechanism of spinal cord IRI. …

[HTML][HTML] … ARTICLE: miR-320a affects spinal cord edema through negatively regulating aquaporin-1 of blood–spinal cord barrier during bimodal stage after ischemia …

XQ Li, B Fang, WF Tan, ZL Wang, XJ Sun, ZL Zhang… - BMC neuroscience, 2016 - Springer
cord IR and to further clarify the underlying mechanisms … expression by posttranscriptional
mechanisms in many biologic … AQP 3 in mice with intestinal ischemic injury [13]. Furthermore, …

Advance in spinal cord ischemia reperfusion injury: Blood–spinal cord barrier and remote ischemic preconditioning

Q Yu, J Huang, J Hu, H Zhu - Life sciences, 2016 - Elsevier
… In this study, we review the morphological structure and function of the BSCB, the injury
mechanism of BSCB resulting from spinal cord I/R, and the effect of RIPC on it. …

… ischemia-induced paralysis in an aortic aneurysm repair mouse model: Utility of immunohistochemistry and histopathology in understanding etiology of spinal cord …

H Awad, A Bratasz, G Nuovo, R Burry, X Meng… - Annals of diagnostic …, 2018 - Elsevier
cord injury and diagnostic pathologists, by using immunohistochemistry, can clarify if this
mechanism also is important in other ischemic … in particular by a bimodal release of chemokines …

[HTML][HTML] … pair CXCL10/CXCR3 initiates sequential glial activation and crosstalk during the development of bimodal inflammatory pain after spinal cord ischemia …

Q Yu, DL Tian, Y Tian, XT Zhao, XY Yang - Cellular Physiology and …, 2018 - karger.com
… Spinal cord ischemia-reperfusion (IR) injury is considered the greatest clinical challenge …
The pathophysiological mechanisms are multifactorial and have not been completely elucidated…

Spinal cord ischemia: development of a model in the mouse

L Lang-Lazdunski, K Matsushita, L Hirt, C Waeber… - Stroke, 2000 - Am Heart Assoc
cord ischemia in the mouse. Therefore, we sought to develop a model of spinal cord ischemia
… for the clarification of patterns and mechanisms of cellular injury after spinal cord ischemia. …

Spinal cord ischemia–reperfusion injury: MicroRNAs and mitophagy at a crossroads

LB Balsam - The Journal of Thoracic and Cardiovascular Surgery, 2017 - jtcvs.org
… the cellular and molecular mechanisms involved in spinal cord ischemia–reperfusion injury
… Role of autophagy in the bimodal stage after spinal cord ischemia reperfusion injury in rats. …