… In the process, we uncover some unexpected similarities and differences with the mechanism
of HDAC1/2 recruitment in the NuRD corepressor complex; we also show that the mode of …

… crystallized and solved the structure of SERM-bound ERαLBD in complex with both an affinity-…
previous structural information on corepressor binding to NRs and provides novel insights …

… Three regions of the corepressor have been reported to mediate interaction with HDAC3 (…
to the corepressor complex. Interesting, the assembly of the HDAC3/DAD complex is itself …

… They act as “platform proteins” in recruiting a corepressor complex ( … The structural basis
obtained from the SPOC/p-SMRT-C8 complex structure in conjunction with SPR analysis was …

… structural biology. In this review, based on specific examples from the European SPINE2-COMPLEXES
initiative, we illustrate the impact of structural … release of corepressor and binding …

… structure of Arabidopsis TPL, which is structurally similar to the previously determined
TPR2 structure from rice (23). Our analyses shed light on this essential plant corepressor; we …

… the NMR structure of the interface complex between GPS2 and SMRT. These structures,
together … assays, reveal the assembly mechanism and stoichiometry of the corepressor complex. …

… structure and its mechanism of corepressor recruitment. In this paper, we present the crystal
structure of SHP in complex … Our structural and biochemical studies reveal an unexpected …

At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-repressor
complex, that is, a multi-protein complex recruited to chromatin by DNA bound …

… linked to loss of NCoR and SMRT corepressor complexes in luminal A breast tumors [89].
In another study that examines ERα corepressor levels in breast cancer, NCoR levels were …