A2A-Adenosine Receptor Reserve for Coronary Vasodilation

JC Shryock, S Snowdy, PG Baraldi, B Cacciari… - Circulation, 1998 - Am Heart Assoc
… interstitial adenosine-induced coronary vasodilation is reported to be … receptor activation to
coronary vasodilation is very efficient. The action of adenosine to cause coronary vasodilation

The paradox of adrenergic coronary vasoconstriction.

EO Feigl - Circulation, 1987 - Am Heart Assoc
… that adrenergic coronary vasoconstriction is a normal part of generalized sympathetic activation
and … of metabolic vasodilation secondary to myocardial fl-receptor activation and direct a-…

Mechanism of coronary vasodilation produced by bradykinin.

LR Pelc, GJ Gross, DC Warltier - Circulation, 1991 - Am Heart Assoc
… The mechanism of coronary vasodilation by bradykinin was studied in open-chest, … B2
receptor activation, and endothelium-derived relaxing factor in bradykinin-mediated vasodilation

Adenosine and maximum coronary vasodilation in humans: myth and misconceptions in the assessment of coronary reserve

G Heusch - Basic research in cardiology, 2010 - Springer
… its anti-adrenergic action after adenosine A 1 receptor activation [43]. Adenosine acts as a
coronary dilator, largely through activation of adenosine A 2A receptors [43, 45]. In humans, …

Coronary Vasodilation and Improvement in Endothelial Dysfunction With Endothelin ETA Receptor Blockade

JPJ Halcox, KRA Nour, G Zalos… - Circulation research, 2001 - Am Heart Assoc
… We demonstrate that ET-1–mediated ET A receptor activation contributes to resting coronary
vasoconstrictor tone in patients with atherosclerosis or its risk factors, confirming findings …

Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease

A Sato, K Terata, H Miura, K Toyama… - American Journal …, 2005 - journals.physiology.org
vasodilation through A 2a receptor activation in pig coronary arterioles (18) and through an
A 2b receptor mechanism in human small coronary … 2a , and A 2b receptors expressed in the …

Clinical importance of coronary endothelial vasodilator dysfunction and therapeutic options

MB Britten, AM Zeiher… - Journal of internal …, 1999 - Wiley Online Library
… such as sympathetic activation as well as impaired vasodilator function of … to activate the
endothelium. Whereas acetylcholine or catecholamines lead to stimulation by receptor activation

Pharmacology of coronary vasodilation: a brief review

C Orlandi - Journal of Nuclear Cardiology, 1996 - Elsevier
… and activates specific cell surface receptors A a and A 2. In vascular smooth muscle, A 2receptor
activation … s Similarly, activation of A~-receptors stimulates synthesis of cyclic guanosine …

The A2A adenosine receptor mediates coronary vasodilation

L Belardinelli, JC Shryock, S Snowdy, Y Zhang… - … of Pharmacology and …, 1998 - ASPET
coronary vasodilation caused by adenosine is due to activation of A 2 adenosine receptors
(… that A 2A AdoRs mediate coronary vasodilation caused by exogenous or endogenous …

Role of A2A‐adenosine receptor activation for ATP‐mediated coronary vasodilation in guinea‐pig isolated heart

KS Erga, CN Seubert, HX Liang, L Wu… - British journal of …, 2000 - Wiley Online Library
… We examined whether coronary vasodilation caused by … 2 receptor activation or by A 2A
-adenosine receptor activation. … of P 2Y receptor activation to the observed coronary vasodilation