… involving the covalent cross-linking of biomolecules, and these functionalities can be
incorporated in various different ways. Each of the different types of cross-linking functionality …

… the interacting protein upon protein–protein interaction, thus covalently cross-linking the
interacting … cell compatibility and of chemical cross-linking to achieve spontaneous reactivity and …

… , the present study aimed to determine the extent to which covalent cross-linking within …
To address our aim, a switchable three-dimensional molecular framework was employed, …

… of the NC2 cross-linking time course. At just 5 min, a gel shift, composed of one αβ complex
covalently … However, in this study two different reagents were applied, giving the same result. …

… In summary, non-covalent interactions play a crucial role in … For this reason, the study of the
biophysical interactions among … cross-linking, combined with MALDI-MS, for the analysis of …

… The analytical advantage of using cross-linking to study biomolecular complexes is that
weak, non-covalent molecular interactions are ‘frozen’ in a chemically stable, covalent …

… Activation by UV light induces covalent cross-linking (see paragraph ‘photoreactive cross-linkers’).
The preference for methionine, leucine, and isoleucine implies that transmembrane …

… cross-linking studies is performed in a “bottom-up” approach, whereby after the cross-linking
reaction the covalently … and the resulting peptide mixtures are analyzed by LC-MS/MS (…

… The major aim of the cross-linking reaction is the formation of a covalent bond between two
spatially proximate residues within a single or between two polypeptide chains. Unfortunately…

… to uncovering the molecular details underlying various cellular activities. To advance the
study of PPIs in living cells, we have developed a new in vivo cross-linking mass spectrometry …