[HTML][HTML] The rationale for angiotensin receptor neprilysin inhibitors in a multi-targeted therapeutic approach to COVID-19

A Bellis, C Mauro, E Barbato, B Trimarco… - International Journal of …, 2020 - mdpi.com
COVID-19 patients. The current review aims to summarize actual therapeutic strategies …
COVID-19 and to examine the data supporting the potential benefits of SAC/VAL in COVID-19

[HTML][HTML] Angiotensin receptorneprilysin inhibition in acute myocardial infarction

MA Pfeffer, B Claggett, EF Lewis… - … England Journal of …, 2021 - Mass Medical Soc
… We estimated that following 5650 patients for a mean duration of 19 months would provide
… The unanticipated coronavirus disease 2019 pandemic prompted a protocol amendment for …

[HTML][HTML] Neprilysin inhibitors and angiotensin (1–7) in COVID-19

N Esser, S Zraika - The British journal of cardiology, 2020 - ncbi.nlm.nih.gov
… In conclusion, the possibility that dual neprilysin inhibition and angiotensin II receptor
blockade could significantly augment levels of the protective peptide angiotensin(1–7), would …

[HTML][HTML] Renin-angiotensin system inhibition in COVID-19 patients

AAF De Vries - Netherlands Heart Journal, 2020 - Springer
… (ACEIs) and angiotensin II type‑1 receptor blockers (ARBs) … the use of AT1R-neprilysin
inhibitors (ARNIs) instead of ACEIs … receptor antagonists and mineralocorticoid receptor blockers. …

[HTML][HTML] Angiotensin receptor blocker neprilysin inhibitors

D Usuda, T Higashikawa, Y Hotchi… - World Journal of …, 2021 - ncbi.nlm.nih.gov
coronavirus 2 — namely, infections of coronavirus disease-2019 (COVID-19) — and
neprilysin/AT1R inhibitor SAC/… AT1Rs required for ACE2 endocytosis in COVID-19 infections[27]. …

Angiotensin-converting enzyme 2 and antihypertensives (angiotensin receptor blockers and angiotensin-converting enzyme inhibitors) in coronavirus disease 2019

F Sanchis-Gomar, CJ Lavie, C Perez-Quilis… - Mayo Clinic …, 2020 - Elsevier
… renin-angiotensin-aldosterone system and COVID-19 infection. … inhibitors. The Canadian
Cardiovascular Society also recommended continuing angiotensin receptor neprilysin inhibitors

Targeting Neprilysin (NEP) pathways: A potential new hope to defeat COVID-19 ghost

MM El Tabaa, MM El Tabaa - Biochemical Pharmacology, 2020 - Elsevier
angiotensin converting enzyme into angiotensin II. Angiotensin II acts via angiotensin II type
1 receptor … can be counteracted via stimulating angiotensin II type 2 receptor. The second …

[HTML][HTML] … Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin …

GJ Moore, H Ridgway, K Kelaidonis, CT Chasapis… - Molecules, 2022 - mdpi.com
… In the present study, a series of 17 conventional angiotensin receptor blockers (ARBs),
including four novel bisartans (BisA–BisD) and two potent NEP antagonists, LBQ657 and …

COVID-19 and angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: what is the evidence?

AB Patel, A Verma - Jama, 2020 - jamanetwork.com
… from vasoconstriction with angiotensin II to vasodilation with Mas receptor activation in
the … of COVID-19 is unclear but some animal data suggest a link. ACE2 and angiotensin (1-7) …

Effects of the angiotensinreceptor neprilysin inhibitor on cardiac reverse remodeling: meta‐analysis

Y Wang, R Zhou, C Lu, Q Chen, T Xu… - Journal of the American …, 2019 - Am Heart Assoc
… The current results suggest that an angiotensinreceptor neprilysin inhibitor can improve …
fraction versus angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers, with …