… overactivation of the complement cascade? In this review, we summarize the literature on
thrombotic complications in COVID-19, complement activation in coronavirus infections, and …

… Coronavirus and complement.A, Simplified diagram of the common complement pathway.
Eculizumab … B, In humans, overactivation of the complement pathway can lead to thrombotic …

… complement activation fragments. The clinicopathologic presentation of COVID‐19 thus parallels
that of other thrombotic … the complement system. This raises the specter that many of the …

… , complement system activation, and immune response to the SARS-CoV-2 virus is a
surprisingly major factor in COVID-19 pathogenesis. One could envision COVID-19 becoming a …

… in the treatment of COVID‐19. This review describes the role of the complement pathway and
… pathogenic virus infections, and therefore its potential as a therapeutic target in COVID‐19. …

… of how or which complement system pathway is activated, … that seen in patients with COVID-19.
More importantly, activation … thrombosis and the consumption of coagulation factors (19) …

… patients with COVID-19 exhibit a thrombotic necrotizing injury … The complement system is
part of the innate immune system … classical pathway, the mannose-binding lectin (MBL) pathway…

… endothelial damage, complement-associated blood clotting and systemic microangiopathy,
… role of the complement system in inducing systemic endothelial dysfunction in COVID-19. …

… complement-dependent cytotoxic tissue damage with detrimental effects in coronavirus disease
2019 (COVID-19) … storm and thrombogenesis in COVID-19, the complement system is an …

… A recently published case series aimed to evaluate the contribution of the complement
system in 2 subsets of COVID-19 patients with lung and skin manifestations. The primary …