Combination therapies for COVID19: An overview of the clinical trials landscape

S Akinbolade, D Coughlan, R Fairbairn… - British journal of …, 2022 - Wiley Online Library
… % of global COVID-19 clinical trials are testing combination therapies, with the majority
exploring dual combinations. As of 29 March 2021, there are 26 dual combination pivotal trials, of …

Combination therapy of tocilizumab and steroid for COVID19 patients: A meta‐analysis

M Moosazadeh, T Mousavi - Journal of medical virology, 2022 - Wiley Online Library
… the treatment of advanced stage of COVID-19 and the reduction of mechanical ventilators …
the role of combination therapy with tocilizumab and steroids in COVID-19 patients. Relevant …

Potential of heparin and nafamostat combination therapy for COVID19

H Asakura, H Ogawa - Journal of Thrombosis and Haemostasis, 2020 - jthjournal.org
… be noted with caution in COVID-19. Most reports concerning COVID-19 non-survivors have
… may be an option to assess the prognosis of COVID-19. Tang et al reported that heparin (…

[HTML][HTML] Co-infections among patients with COVID-19: The need for combination therapy with non-anti-SARS-CoV-2 agents?

CC Lai, CY Wang, PR Hsueh - Journal of Microbiology, Immunology and …, 2020 - Elsevier
… on co-infection among patients with coronavirus disease 2019 (COVID-19). The prevalence
of co-infection was variable among COVID-19 patients in different studies, however, it could …

Early combination therapy of COVID-19 in high-risk patients

HM Orth, C Flasshove, M Berger, T Hattenhauer… - Infection, 2023 - Springer
… In our cohort of 144 mainly immunocompromised patients receiving first-line combination
therapies for COVID-19, clinical courses were mild to moderate and prolonged viral shedding …

Effect of Aprotinin and Avifavir® Combination Therapy for Moderate COVID-19 Patients

AA Ivashchenko, VN Azarova, AN Egorova… - Viruses, 2021 - mdpi.com
… Our findings demonstrates that therapy with a combination of aprotinin with Avifavir ® … in
patients hospitalized with COVID-19-associated pneumonia and requiring oxygen therapy, as …

[HTML][HTML] Accelerating clinical evaluation of repurposed combination therapies for COVID-19

CR Rayner, L Dron, JJH Park, EH Decloedt… - The American Journal …, 2020 - ncbi.nlm.nih.gov
… efficacy of potential therapies for COVID-19 is through studying combination therapies, ideally
with … the development of repurposed drugs as combination therapies to treat COVID-19. …

The IDentif. AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens

A Blasiak, ATL Truong, A Remus, L Hooi… - NPJ Digital …, 2022 - nature.com
… pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a … 50
combination regimens at three dosing levels per drug, representing 729 possible combinations. …

Sequential doxycycline and colchicine combination therapy in Covid-19: the salutary effects

HM Al-Kuraishy, AI Al-Gareeb, N Qusty… - Pulmonary …, 2021 - Elsevier
… ALI, studies addressing the effect of a planned combination therapy are warranted. Thus, in
COVID-19 pneumonia who developed ALI. The patients in addition to the supportive therapy

Derivatization and combination therapy of current COVID-19 therapeutic agents: a review of mechanistic pathways, adverse effects, and binding sites

S El Kantar, B Nehmeh, P Saad, G Mitri, C Estephan… - Drug Discovery …, 2020 - Elsevier
… We proposed combination therapy using current COVID-19 repurposed drugs. … Although
combination therapy involving two or more of the current and potential COVID-19 agents could …