Vascular endothelial damage in the pathogenesis of organ injury in severe COVID-19

…, Lille Covid Research Network (LICORNE) - … and Vascular Biology, 2021 - Am Heart Assoc
… Using cultured human pulmonary microvascular endothelial cells, we demonstrated that …
COVID-19 triggers endothelial damage in vitro. Interestingly, this plasma-induced endothelial

COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure

M Marchetti - Annals of hematology, 2020 - Springer
… to endothelial dysfunction and aberrant coagulation in small and large vessels. This review
addresses some of the pathways leading to endothelial … of COVID-19-related organ damage

Endothelial cells orchestrate COVID-19 coagulopathy

JM O'Sullivan, D Mc Gonagle, SE Ward… - The Lancet …, 2020 - thelancet.com
… associated with severe COVID-19 are thus suggestive of fulminant endothelial cell activation…
) are also significantly elevated in patients with COVID-19 who are admitted to the ICU (15·9 …

[HTML][HTML] Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy

J Zhang, KM Tecson, PA McCullough - Reviews in cardiovascular …, 2020 - imrpress.com
… were dramatically elevated in patients with COVID-19-associated coagulopathy, particularly
in … Therefore, the culprit in COVID-19-associated coagulopathy is endothelial activation in …

Vascular endothelial glycocalyx damage in COVID-19

M Yamaoka-Tojo - International Journal of Molecular Sciences, 2020 - mdpi.com
… numerous reports of VEGLX damage in acute respiratory … to vascular endothelial damage
in severe COVID-19. Recently, … reports on COVID-19 and VEGLX damage along with their …

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

F D'Agnillo, KA Walters, Y Xiao, ZM Sheng… - Science Translational …, 2021 - science.org
… direct blood vessel damage, highlight the critical pathogenic involvement of endothelial
dysfunction in severe COVID-19 (6, 7). Key risk factors associated with severe COVID-19 include …

Further findings concerning endothelial damage in COVID-19 patients

M Gelzo, S Cacciapuoti, B Pinchera, A De Rosa… - Biomolecules, 2021 - mdpi.com
… Finally, the lack of an increase in serum E-selectin in our COVID-19 patients suggests
that the endothelial damage in these patients is a less relevant, secondary event caused by …

COVID-19 is, in the end, an endothelial disease

P Libby, T Lüscher - European heart journal, 2020 - academic.oup.com
… SARS-CoV-2, the aetiological agent of COVID-19, causes the current pandemic. It produces
… that COVID-19, particularly in the later complicated stages, represents an endothelial

[HTML][HTML] Endothelial dysfunction in COVID-19: Current findings and therapeutic implications

MP Nägele, B Haubner, FC Tanner, F Ruschitzka… - Atherosclerosis, 2020 - Elsevier
endothelial dysfunction and injury. This review provides an overview on the association
of endothelial dysfunction with COVID-19 and its therapeutic implications. Endothelial

Endothelial Dysfunction, Inflammation, and Oxidative Stress in COVID19—Mechanisms and Therapeutic Targets

A Fodor, B Tiperciuc, C Login… - Oxidative medicine …, 2021 - Wiley Online Library
… is an important pathological characteristic in COVID-19 [20]. Electron microscopy of … COVID-19
revealed the presence of endothelial cell degradation and apoptosis [21, 22]. Endothelial